|
16 (1.11, 1.22) |
|
|
|
|
(43 doses) |
(15 doses) |
17 |
↑ |
1.22 (1.11, 1.34) |
1.26 (1.15, 1.38) |
1.35 (1.22, 1.50) |
|
Clarithromycin |
500 mg BID
(25 doses) |
500/200 mg BID
(15 doses) |
21 |
↑ |
0.95 (0.83, 1.09) |
1.19 (1.04, 1.37) |
1.68 (1.42, 1.98) |
|
14-OH-clarithromycin |
|
|
21 |
↓ |
0.03 (0.02, 0.04) |
0.03 (0.02, 0.04) |
0.05 (0.04, 0.07) |
|
Didanosinec |
200 mg BID, ≥60 kg
125 mg BID, <60 kg
(43 doses) |
250/200 mg BID
750/100 mg BID
1250/100 mg BID
(42 doses) |
10
8
9 |
↓
↔
↔ |
0.57 (0.42, 0.79)
0.76 (0.49, 1.17)
0.77 (0.47, 1.26) |
0.67 (0.51, 0.88)
0.97 (0.64, 1.47)
0.87 (0.47, 1.65) |
-
-
- |
|
|
400 mg
(1 dose) |
500/100 mg BID
(27 doses) |
5 |
↔ |
0.80 (0.63, 1.02) |
0.90 (0.72, 1.11) |
1.17 (0.62, 2.20) |
|
Efavirenzc |
600 mg QD
(15 doses) |
500/100 mg BID
750/200 mg BID
(15 doses) |
24
22 |
↔
↔ |
1.09 (0.99, 1.19)
1.12 (0.98, 1.28) |
1.04 (0.97, 1.12)
1.00 (0.93, 1.09) |
1.02 (0.92, 1.12)
0.94 (0.84, 1.04) |
|
Ethinyl estradiol |
0.035 mg
(1 dose) |
500/100 mg BID
750/200 mg BID
(21 doses) |
21
13 |
↓
↓ |
0.52 (0.47, 0.57)
0.48 (0.42, 0.57) |
0.52 (0.48, 0.56)
0.57 (0.54, 0.60) |
-
- |
|
Fluconazole |
200 mg (Day 1) then
100 mg QD
(6 or 12 doses) |
500/200 mg BID
(2 or 14 doses) |
19
19 |
↔
↔ |
0.97 (0.94, 1.01)
0.94 (0.91, 0.98) |
0.99 (0.97, 1.02)
0.92 (0.88, 0.95) |
0.98 (0.94, 1.02)
0.89 (0.85, 0.92) |
|
Lopinavir/ritonavira |
400/100 mg BID
(27 doses) |
500/200 mg BID
(28 doses) |
21
69 |
↓
↓ |
0.53 (0.40, 0.69)e
- |
0.45 (0.32, 0.63)e
- |
0.30 (0.17, 0.51)e
0.48 (0.40, 0.58)f |
|
Loperamide |
16 mg
(1 dose) |
750/200 mg BID
(21 doses) |
24 |
↓ |
0.39 (0.31, 0.48) |
0.49 (0.40, 0.61) |
- |
|
N-Demethyl-Loperamide |
|
|
24 |
↓ |
0.21 (0.17, 0.25) |
0.23 (0.19, 0.27) |
- |
|
Lamivudinea |
150 mg BID
(43 doses) |
250/200 mg BID
750/100 mg BID
1250/100 mg BID
(42 doses) |
64
46
35 |
↔
↔
&har |
