d in a hospital. Call your healthcare provider right away if you experience any of these symptoms.
•Skin rash or acne
•Dry skin
•Itching
•Blisters on your skin
•Blisters or sores in your mouth
•Peeling of your skin
•Fever
•Muscle or joint aches
•Redness or swelling of your face, hands, or soles of your feet
•Breathing problems (interstitial lung disease). Vandetanib may cause a breathing problem called interstitial lung disease that can lead to death. Tell your healthcare provider right away if you experience sudden or worsening shortness of breath or cough.
•Stroke. Strokes have been reported in some people who have taken Vandetanib and in some cases have caused death. Stop taking Vandetanib and call your healthcare provider right away if you have symptoms of a stroke which may include:
◦numbness or weakness of the face, arm or leg, especially on one side of the body
◦sudden confusion, trouble speaking or understanding
◦sudden trouble seeing in one or both eyes
◦sudden trouble walking, dizziness, loss of balance or coordination
◦sudden, severe headache
•Bleeding. Bleeding can happen during your treatment with Vandetanib. Tell your healthcare provider right away if you have severe bleeding while you are taking Vandetanib.
•Heart failure. Vandetanib can cause heart failure that can lead to death. You may have to stop taking Vandetanib if you have heart failure. Heart failure may not be reversible after stopping Vandetanib. Your healthcare provider should monitor you for signs and symptoms of heart failure.
•Diarrhea. Diarrhea is often a symptom of medullary thyroid cancer. Vandetanib can also cause diarrhea or make diarrhea worse. Your healthcare provider should check your blood levels to monitor your electrolytes more frequently if you have diarrhea.
•Thyroid hormones. You can have changes in your thyroid hormone when taking Vandetanib. Your healthcare provider should monitor your thyroid hormone levels while taking Vandetanib.
•High blood pressure (hypertension). If you develop high blood pressure or your high blood pressure gets worse, your healthcare provider may lower your dose of Vandetanib or tell you to stop taking Vandetanib until your blood pressure is under control. Your healthcare provider may prescribe another medicine to control your high blood pressure.
•Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome can happen while taking Vandetanib. Call your healthcare provider right away if you have:
•headaches
•seizures
•confusion
•changes in vision
•problems thinking
The most common side effects of Vandetanib include:
•diarrhea
•rash
•acne
•nausea
•high blood pressure
•headache
•feeling tired
•loss of appetite
•stomach (abdominal) pain
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Vandetanib. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store Vandetanib?
•Store Vandetanib tablets at 59 |
