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VIEKIRA XR(dasabuvir, ombitasvir, paritaprevir, and ritonavir)extended-release tablets(二十五)
ly
in the evening 10 0.79
(0.70, 0.90)b 1.34
(1.25, 1.43)b 0.54
(0.48, 0.62)b
Diazepam 2 single dose 13 1.18
(1.07, 1.30) 0.78
(0.73, 0.82) NA
Diazepam's
metabolite,
nordiazepam 1.10
(1.03, 1.19) 0.56
(0.45, 0.70) NA
Ethinyl Estradiol Ethinyl
estradiol 0.035
and Norgestimate
0.25 once daily 8 1.16
(0.90, 1.50) 1.06
(0.96, 1.17) 1.12
(0.94, 1.33)
Norelgestromin 9 2.01
(1.77, 2.29) 2.60
(2.30, 2.95) 3.11
(2.51, 3.85)
Norgestrel 9 2.26
(1.91, 2.67) 2.54
(2.09, 3.09) 2.93
(2.39, 3.57)
Everolimus 0.75 single dose 12 4.74
(4.29, 5.25) 27.12
(24.5, 30.1) 16.10
(14.5, 17.9)
Furosemide 20 single dose 12 1.42
(1.17, 1.72) 1.08
(1.00, 1.17) NA
Hydrocodone 5 single dose 15 1.27
(1.14, 1.40) 1.90
(1.72, 2.10) NA
Ketoconazole 400 once daily 12 1.15
(1.09, 1.21) 2.17
(2.05, 2.29) NA
Lopinavir/
ritonavir 400/100
twice daily 6 0.87
(0.76, 0.99)b 0.94
(0.81, 1.10)b 1.15
(0.93, 1.42)b
Lopinavir/
ritonavirh 800/200
once daily 12 0.86
(0.80, 0.93)b 0.94
(0.87, 1.01)b 3.18
(2.49, 4.06)b
Omeprazole 40 once daily 11 0.62
(0.48, 0.80) 0.62
(0.51, 0.75) NA
Pravastatin 10 once daily 12 1.37
(1.11, 1.69) 1.82
(1.60, 2.08) NA
Rilpivirine 25 once daily
(morning)i 8 2.55
(2.08, 3.12) 3.25
(2.80, 3.77) 3.62
(3.12, 4.21)
Rosuvastatin 5 once daily 11 7.13
(5.11, 9.96) 2.59
(2.09, 3.21) 0.59
(0.51, 0.69)
Sirolimus 0.5 single dosej 11 6.40
(5.34, 7.68)c 37.99
(31.5, 45.8)c 19.55
(16.7, 22.9)c
Tacrolimus 2 single dose 12 3.99
(3.21, 4.97)c 57.13
(45.53, 71.69)c 16.56
(12.97, 21.16)c
Atazanavir plus 100 mg ritonavir administered in the evening, 12 hours after morning dose of the components of VIEKIRA XR.
Atazanavir or darunavir or lopinavir parameters are reported.
Dose normalized parameters reported.
30 mg cyclosporine was administered with the components of VIEKIRA XR in the test arm and 100 mg cyclosporine was administered in the reference arm without the components of VIEKIRA XR.
Darunavir administered with the components of VIEKIRA XR in the morning was compared to darunavir administered with 100 mg ritonavir in the morning.
Darunavir administered with the components of VIEKIRA XR in the morning and with 100 mg ritonavir in the evening was compared to darunavir administered with 100 mg ritonavir in the morning and evening.
Darunavir plus 100 mg ritonavir administered in the evening, 12 hours after morning dose of the components of VIEKIRA XR compared to darunavir administered with 100 mg ritonavir in the evening.
Lopinavir/ritonavir administered in the evening, 12 hours after morning dose of the components of VIEKIRA XR.
Similar increases were observed when rilpivirine was dosed in the evening with food or 4 hours after food.
0.5 mg sirolimu |
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