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VIEKIRA XR(dasabuvir, ombitasvir, paritaprevir, and ritonavir)extended-release tablets(二十三)
nbsp;1.02
(0.97, 1.08) 0.97
(0.89, 1.05)
Pravastatin 10 once daily 12 dasabuvir 1.00
(0.87, 1.14) 0.96
(0.85, 1.09) 1.03
(0.91, 1.15)
ombitasvir 0.95
(0.89, 1.02) 0.94
(0.89, 0.99) 0.94
(0.89, 0.99)
paritaprevir 0.96
(0.69, 1.32) 1.13
(0.92, 1.38) 1.39
(1.21, 1.59)
ritonavir 0.89
(0.73, 1.09) 0.95
(0.86, 1.05) 1.08
(0.98, 1.19)
Rilpivirine 25 once daily
(morning)i 10 dasabuvir 1.18
(1.02, 1.37) 1.17
(0.99, 1.38) 1.10
(0.89, 1.37)
ombitasvir 1.11
(1.02, 1.20) 1.09
(1.04, 1.14) 1.05
(1.01, 1.08)
paritaprevir 1.30
(0.94, 1.81) 1.23
(0.93, 1.64) 0.95
(0.84, 1.07)
ritonavir 1.10
(0.98, 1.24) 1.08
(0.93, 1.27) 0.97
(0.91, 1.04)
Rosuvastatin 5 once daily 11 dasabuvir 1.07
(0.92, 1.24) 1.08
(0.92, 1.26) 1.15
(1.05, 1.25)
ombitasvir 0.92
(0.82, 1.04) 0.89
(0.83, 0.95) 0.88
(0.83, 0.94)
paritaprevir 1.59
(1.13, 2.23) 1.52
(1.23, 1.90) 1.43
(1.22, 1.68)
ritonavir 0.98
(0.84, 1.15) 1.02
(0.93, 1.12) 1.00
(0.90, 1.12)
Sirolimus 0.5 single
dosej 11 ombitasvir 1.03
(0.93, 1.15) 1.02
(0.96, 1.09) 1.05
(0.98, 1.12)
paritaprevir 1.18
(0.91, 1.54) 1.19
(0.97, 1.46) 1.16
(1.00, 1.34)
ritonavir 1.00
(0.85, 1.17) 1.04
(0.94, 1.15) 1.10
(1.04, 1.17)
dasabuvir 1.04
(0.89, 1.22) 1.07
(0.95, 1.22) 1.13
(1.01, 1.25)
Tacrolimus 2 single dose 12 dasabuvir 0.85
(0.73, 0.98) 0.90
(0.80, 1.02) 1.01
(0.91, 1.11)
ombitasvir 0.93
(0.88, 0.99) 0.94
(0.89, 0.98) 0.94
(0.91, 0.96)
paritaprevir 0.57
(0.42, 0.78) 0.66
(0.54, 0.81) 0.73
(0.66, 0.80)
ritonavir 0.76
(0.63, 0.91) 0.87
(0.79, 0.97) 1.03
(0.89, 1.19)
Atazanavir plus 100 mg ritonavir administered in the evening, 12 hours after morning dose of the components of VIEKIRA XR.
30 mg cyclosporine was administered with the components of VIEKIRA XR in the test arm and 100 mg cyclosporine was administered in the reference arm without the components of VIEKIRA XR.
Darunavir administered with the components of VIEKIRA XR in the morning was compared to darunavir administered with 100 mg ritonavir in the morning.
Darunavir administered with the components of VIEKIRA XR in the morning and with 100 mg ritonavir in the evening was compared to darunavir administered with 100 mg ritonavir in the morning and evening.
Darunavir plus 100 mg ritonavir administered in the evening, 12 hours after the morning dose of the components of VIEKIRA XR compared to darunavir administered with 100 mg ritonavir in the evening.
N=3 for dasabuvir.
Study was conducted with paritaprevir, ritonavir and dasabuvir.
Lopinavir/ritonavir administered in the evening, 12 hours after morning dose of the components of VIEKIRA XR.
Similar increases were observed when rilpivirine was dosed in the evening with food or 4 hours after food.
0.5 mg sirolimus was admini |
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