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VIEKIRA XR(dasabuvir, ombitasvir, paritaprevir, and ritonavir)extended-release tablets(二十二)
avir 0.80
(0.53, 1.21) 0.71
(0.54, 0.94) 0.79
(0.68, 0.93)
Everolimus 0.75 single
dose 12 ombitasvir 0.99
(0.95, 1.03) 1.02
(0.99, 1.05) 1.02
(0.99, 1.06)
paritaprevir 1.22
(1.03, 1.43) 1.26
(1.07, 1.49) 1.06
(0.97, 1.16)
ritonavir 1.07
(0.99, 1.16) 1.05
(1.00, 1.10) 1.07
(1.02, 1.13)
dasabuvir 1.03
(0.90, 1.18) 1.08
(0.98, 1.20) 1.14
(1.05, 1.23)
Furosemide 20 single
dose 12 dasabuvir 1.12
(0.96, 1.31) 1.09
(0.96, 1.23) 1.06
(0.98, 1.14)
ombitasvir 1.14
(1.03, 1.26) 1.07
(1.01, 1.12) 1.12
(1.08, 1.16)
paritaprevir 0.93
(0.63, 1.36) 0.92
(0.70, 1.21) 1.26
(1.16, 1.38)
ritonavir 1.10
(0.96, 1.27) 1.04
(0.92, 1.18) 1.07
(0.99, 1.17)
Gemfibrozilg 600 twice daily 11 dasabuvir 2.01
(1.71, 2.38) 11.25
(9.05, 13.99) NA
ombitasvir NA NA NA
paritaprevir 1.21
(0.94, 1.57) 1.38
(1.18, 1.61) NA
ritonavir 0.84
(0.69, 1.03) 0.90
(0.78, 1.04) NA
Hydrocodone/
Acetaminophen 5/300 single
dose 15 dasabuvir 1.13
(1.01, 1.26) 1.12
(1.05, 1.19) 1.16
(1.08, 1.25)
ombitasvir 1.01
(0.93, 1.10) 0.97
(0.93, 1.02) 0.93
(0.90, 0.97)
paritaprevir 1.01
(0.80, 1.27) 1.03
(0.89, 1.18) 1.10
(0.97, 1.26)
ritonavir 1.01
(0.90, 1.13) 1.03
(0.96, 1.09) 1.01
(0.93, 1.10)
Ketoconazole 400 once daily 12 dasabuvir 1.16
(1.03, 1.32) 1.42
(1.26, 1.59) NA
ombitasvir 0.98
(0.90, 1.06) 1.17
(1.11, 1.24) NA
paritaprevir 1.37
(1.11, 1.69) 1.98
(1.63, 2.42) NA
ritonavir 1.27
(1.04, 1.56) 1.57
(1.36, 1.81) NA
Lopinavir/
ritonavir 400/100 twice daily 6 dasabuvir 0.99
(0.75, 1.31) 0.93
(0.75, 1.15) 0.68
(0.57, 0.80)
ombitasvir 1.14
(1.01, 1.28) 1.17
(1.07, 1.28) 1.24
(1.14, 1.34)
paritaprevir 2.04
(1.30, 3.20) 2.17
(1.63, 2.89) 2.36
(1.00, 5.55)
ritonavir 1.55
(1.16, 2.09) 2.05
(1.49, 2.81) 5.25
(3.33, 8.28)
Lopinavir/
ritonavirh 800/200 once daily 12 dasabuvir 0.56
(0.47, 0.66) 0.54
(0.46, 0.65) 0.47
(0.39, 0.58)
ombitasvir 0.87
(0.83, 0.92) 0.97
(0.94, 1.02) 1.11
(1.06, 1.16)
paritaprevir 0.99
(0.79, 1.25) 1.87
(1.40, 2.52) 8.23
(5.18, 13.07)
ritonavir 1.57
(1.34, 1.83) 2.62
(2.32, 2.97) 19.46
(15.93, 23.77)
Omeprazole 40 once daily 11 dasabuvir 1.13
(1.03, 1.25) 1.08
(0.98, 1.20) 1.05
(0.93, 1.19)
ombitasvir 1.02
(0.95, 1.09) 1.05
(0.98, 1.12) 1.04
(0.98, 1.11)
paritaprevir 1.19
(1.04, 1.36) 1.18
(1.03, 1.37) 0.92
(0.76, 1.12)
ritonavir 1.04
(0.96, 1.12)& |
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