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VIEKIRA XR(dasabuvir, ombitasvir, paritaprevir, and ritonavir)extended-release tablets(二十一)
7) 0.96
(0.92, 0.99)
paritaprevir 0.88
(0.75, 1.03) 0.96
(0.85, 1.08) 1.14
(1.02, 1.27)
ritonavir 0.94
(0.87, 1.02) 0.94
(0.88, 0.99) 0.95
(0.89, 1.03)
Cyclobenzaprine 5 single dose 14 dasabuvir 0.98
(0.90, 1.07) 1.01
(0.96, 1.06) 1.13
(1.07, 1.18)
ombitasvir 0.98
(0.92, 1.04) 1.00
(0.97, 1.03) 1.01
(0.98, 1.04)
paritaprevir 1.14
(0.99, 1.32) 1.13
(1.00, 1.28) 1.13
(1.01, 1.25)
ritonavir 0.93
(0.87, 0.99) 1.00
(0.95, 1.06) 1.13
(1.05, 1.21)
Cyclosporine 30 single doseb 10 dasabuvir 0.66
(0.58, 0.75) 0.70
(0.65, 0.76) 0.76
(0.71, 0.82)
ombitasvir 0.99
(0.92, 1.07) 1.08
(1.05, 1.11) 1.15
(1.08, 1.23)
paritaprevir 1.44
(1.16, 1.78) 1.72
(1.49, 1.99) 1.85
(1.58, 2.18)
ritonavir 0.90
(0.78, 1.04) 1.11
(1.04, 1.19) 1.49
(1.28, 1.74)
Darunavirc 800 once daily 9 dasabuvir 1.10
(0.88, 1.37) 0.94
(0.78, 1.14) 0.90
(0.76, 1.06)
ombitasvir 0.86
(0.77, 0.95) 0.86
(0.79, 0.94) 0.87
(0.82, 0.92)
paritaprevir 1.54
(1.14, 2.09) 1.29
(1.04, 1.61) 1.30
(1.09, 1.54)
ritonavir 0.84
(0.72, 0.98) 0.85
(0.78, 0.93) 1.07
(0.93, 1.23)
Darunavir/
ritonavird Darunavir
600 twice daily and
ritonavir 100 once daily
in the evening 7 dasabuvir 0.84
(0.67, 1.05) 0.73
(0.62, 0.86) 0.54
(0.49, 0.61)
ombitasvir 0.76
(0.65, 0.88) 0.73
(0.66, 0.80) 0.73
(0.64, 0.83)
paritaprevir 0.70
(0.43, 1.12) 0.59
(0.44, 0.79) 0.83
(0.69, 1.01)
ritonavir 1.61
(1.30, 2.00) 1.28
(1.12, 1.45) 0.88
(0.79, 0.99)
Darunavir/
ritonavire Darunavir
800 and
ritonavir 100
once daily in the
evening 12 dasabuvir 0.75
(0.64, 0.88) 0.72
(0.64, 0.82) 0.65
(0.58, 0.72)
ombitasvir 0.87
(0.82, 0.93) 0.87
(0.81, 0.93) 0.87
(0.80, 0.95)
paritaprevir 0.70
(0.50, 0.99) 0.81
(0.60, 1.09) 1.59
(1.23, 2.05)
ritonavir 1.19
(1.06, 1.33) 1.70
(1.54, 1.88) 14.15
(11.66, 17.18)
Diazepam 2 single dose 13 dasabuvir 1.05
(0.98, 1.13) 1.01
(0.94, 1.08) 1.05
(0.98, 1.12)
ombitasvir 1.00
(0.93, 1.08) 0.98
(0.93, 1.03) 0.93
(0.88, 0.98)
paritaprevir 0.95
(0.77, 1.18) 0.91
(0.78, 1.07) 0.92
(0.82, 1.03)
ritonavir 1.10
(1.02, 1.19) 1.06
(0.98, 1.14) 0.98
(0.92, 1.03)
Ethinyl estradiol/
Norgestimate Ethinyl
estradiol
0.035 and
Norgestimate
0.25 once daily 7f dasabuvir 0.51
(0.22, 1.18) 0.48
(0.23, 1.02) 0.53
(0.30, 0.95)
ombitasvir 1.05
(0.81, 1.35) 0.97
(0.81, 1.15) 1.00
(0.88, 1.12)
paritaprevir 0.70
(0.40, 1.21) 0.66
(0.42, 1.04) 0.87
(0.67, 1.14)
riton |
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