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GENVOYA(elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide)tablets(二十四)
1.32,1.49) 1.43
(1.36,1.52) 1.51
(1.41,1.62)
Carbamazepine-10,11-epoxide 0.73
(0.70,0.78) 0.65
(0.63,0.66) 0.59
(0.57,0.61)
Desipramine 50 single dose N/A 150 once daily N/A 8 1.24
(1.08,1.44) 1.65
(1.36,2.02) NC
Digoxin 0.5 single dose N/A 150 once daily N/A 22 1.41 (1.29,1.55) 1.08
(1.00,1.17) NC
Ledipasvir 90 once daily 150 once daily† 150 once daily† 10 once daily† 30 1.65
(1.53,1.78) 1.79
(1.64,1.96) 1.93
(1.74,2.15)
Sofosbuvir 400 once daily 1.28
(1.13,1.47) 1.47
(1.35,1.59) N/A
GS-331007‡ 1.29
(1.24,1.35) 1.48
(1.44,1.53) 1.66
(1.60,1.73)
Naloxone 4–6 once daily 150 once daily 150 once daily N/A 17 0.72
(0.61,0.85) 0.72
(0.59,0.87) N/A
Norgestimate/ ethinyl estradiol§ 0.180/0.215/ 0.250 norgestimate once daily 150 once daily§ 150 once daily§ N/A 13 2.08
(2.00,2.17) 2.26
(2.15,2.37) 2.67
(2.43,2.92)
0.025 ethinyl estradiol once daily 0.94
(0.86,1.04) 0.75
(0.69,0.81) 0.56
(0.52,0.61)
Norgestromin 0.180/0.215/ 0.250 norgestimate once daily / 0.025 ethinyl estradiol once daily N/A N/A 25 once daily¶ 29 1.17
(1.07,1.26) 1.12
(1.07,1.17) 1.16
(1.08,1.24)
Norgestrel 1.10
(1.02,1.18) 1.09
(1.01,1.18) 1.11
(1.03,1.20)
Ethinyl estradiol 1.22
(1.15,1.29) 1.11
(1.07,1.16) 1.02
(0.93,1.12)
R-Methadone 80–120 daily 150 once daily 150 once daily N/A 11 1.01
(0.91,1.13) 1.07
(0.96,1.19) 1.10
(0.95,1.28)
S-Methadone 0.96
(0.87,1.06) 1.00
(0.89,1.12) 1.02
(0.89,1.17)
Sertraline 50 single dose 150 once daily† 150 once daily† 10 once daily† 19 1.14
(0.94,1.38) 0.93
(0.77,1.13) N/A
Rifabutin 150 once every other day 150 once daily 150 once daily N/A 12 1.09
(0.98,1.20)# 0.92
(0.83,1.03)# 0.94
(0.85,1.04)#
25-O-desacetyl-rifabutin 12 4.84
(4.09,5.74)# 6.25
(5.08,7.69)# 4.94
(4.04,6.04)#
Rosuvastatin 10 single dose 150 once daily 150 once daily N/A 10 1.89
(1.48,2.42) 1.38
(1.14,1.67) NC
Sofosbuvir 400 once daily 150 once daily† 150 once daily† 10 once daily† 24 1.23
(1.07,1.42) 1.37
(1.24,1.52) N/A
GS-331007‡ 1.29
(1.25,1.33) 1.48
(1.43,1.53) 1.58
(1.52,1.65)
Velpatasvir 100 once daily 1.30 (1.17,1.45) 1.50 (1.35,1.66) 1.60 (1.44,1.78)
12.4 Microbiology
Mechanism of Action
Elvitegravir: Elvitegravir inhibits the strand transfer activity of HIV-1 integrase (integrase strand transfer inhibitor; INSTI), an HI |
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