Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

How should I use FIRAZYR?

• Use FIRAZYR exactly as your healthcare provider tells you to use it.
• Your healthcare provider will prescribe the right dose of FIRAZYR for you and tell you when to use it.
• Your healthcare provider will teach you or a caregiver how to give FIRAZYR injections.
• Read the Instructions for Use at the end of the Patient Information for information about the right way to use FIRAZYR.
• If your symptoms continue or come back, you may repeat your FIRAZYR injection at least six hours apart.
• Do not use more than 3 doses in 24 hours.
• If you have a laryngeal attack, inject FIRAZYR and then go to the nearest hospital emergency room right away.

What should I avoid while using FIRAZYR?

Tiredness, drowsiness, and dizziness can occur in people who take FIRAZYR. If this occurs, do not drive a car, use machinery, or do anything that needs you to be alert.

What are the possible side effects of FIRAZYR?

The most common side effects of FIRAZYR include:

• redness, bruising, swelling, warmth, burning, itching, irritation, hives, numbness, pressure, or pain at the injection site
• fever
• too much of an enzyme called transaminase in your blood
• dizziness
• nausea
• headache
• rash

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of FIRAZYR. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store FIRAZYR?

• Store FIRAZYR between 36°F to 77°F (2°C to 25°C).
• Do not freeze.
• Store FIRAZYR in the original carton until you are ready to use it.

Keep FIRAZYR and all medicines out of the reach of children.

General information about the safe and effective use of FIRAZYR

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use FIRAZYR for a condition for which it was not prescribed. Do not give FIRAZYR to other people, even if they have the same symptoms that you have. It may harm them.

This Patient Information leaflet summarizes the most important information about FIRAZYR. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about FIRAZYR that is written for health professionals.

For more information, go to www.FIRAZYR.com or call 1-866-888-0660.

What are the ingredients in FIRAZYR?

Active ingredient: icatibant acetate

Inactive Ingredients: sodium chloride, glacial acetic acid, sodium hydroxide, and water

Step-by-Step Instructions for your FIRAZYR injection

Step 1. Preparing your dose of FIRAZYR