penicillin G procaine - Drug Summary
CLASSES
Penicillinase-Sensitive Penicillin Antibiotics
DEA CLASS
Rx
DESCRIPTION
Equimolar compound of procaine and penicillin G antibiotic for intramuscular use; tissue depot allows slow drug absorption with plateau type blood concentrations over several hours; used in moderately severe infections due to penicillin G susceptible organisms.
COMMON BRAND NAMES
Wycillin
HOW SUPPLIED
Penicillin/Penicillin G Procaine/Wycillin Intramuscular Inj Susp: 1mL, 2mL, 600000U, 1200000U
DOSAGE & INDICATIONS
For the treatment of moderately severe pneumococcal pneumonia, moderately severe to severe staphylococcal infections, and moderately severe to severe group A streptococcal (GAS) infections (tonsillitis, erysipelas, scarlet fever, upper respiratory tract infections, skin and skin structure infections).
Intramuscular dosage
Adults, Adolescents, and Children weighing 27 kg or more
600,000 to 1.2 million units IM once daily. For group A streptococcal (GAS) infections, treat for at least 10 days. Penicillin G procaine is not recommended as a treatment option in guidelines for community-acquired pneumonia, GAS pharyngitis/rheumatic fever prophylaxis, sinusitis, or skin and skin structure infections.
Infants and Children weighing less than 27 kg
300,000 units IM once daily. For group A streptococcal (GAS) infections, treat for at least 10 days. Penicillin G procaine is not recommended as a treatment option in guidelines for community-acquired pneumonia, GAS pharyngitis/rheumatic fever prophylaxis, sinusitis, or skin and skin structure infections.
For the treatment of subacute bacterial endocarditis due to penicillin-susceptible Group A streptococci.
Intramuscular dosage
Adults
The American Heart Association (AHA) does not recommend penicillin G procaine for endocarditis. Package labeling recommends 600,000—1 million units IM daily.
For the treatment of fusospirochetosis or Vincent's infection (necrotizing ulcerative gingivitis or pharyngitis).
Intramuscular dosage
Adults
600,000—1 million units IM daily.
For the treatment of diphtheria.
For diphtheria carrier state.
Intramuscular dosage
Adults
300,000 units IM once daily for 10 days.
For the treatment of diphtheria.
Intramuscular dosage
Adults, Adolescents, Children, and Infants weighing more than 10 kg
600,000 units IM once daily for 14 days in combination with antitoxin.
Infants and Children weighing 10 kg or less
300,000 units IM once daily for 14 days in combination with antitoxin.
For the treatment of rat-bite fever.
Intramuscular dosage
Adults
600,000—1 million units IM daily.
For the treatment of anthrax.
Intramuscular dosage
Adults
Because of potential resistance issues, penicillin G procaine is not recommended as initial monotherapy, but may be used as add-on therapy. 600,000 units to 1.2 million units IM once or twice daily is recommended. Total treatment is for 60 days.
Infants, Children, and Adolescents
Because of potential resistance issues, penicillin G procaine is not recommended as initial monotherapy, but may be used as add-on therapy. 25,000—50,000 units/kg/dose IM once daily or 25,000 units/kg/dose IM twice daily (Max: 1.2 million units/dose) has been recommended. Adult doses of 600,000 units to 1.2 million units IM once or twice daily have been recommended. Total treatment is for 60 days.
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