s 1.9 hours
Oral Route
Ezetimibe: The absolute bioavailability of ezetimibe is not known. The concomitant administration of food (high-fat vs. non-fat meals) has no effect on the extent of absorption of ezetimibe. However, co-administration with a high-fat meal increases the peak concentration (Cmax) of ezetimibe by 38%.
Simvastatin: Absorption is about 85%, but bioavailability is less than 5%. Absorption is not significantly reduced if taken before a low-fat meal; the drug can be administered with or without food. To optimize the action of simvastatin, it should be administered in the evening hours or at bedtime. Peak plasma concentrations are reached in 1.3—2.4 hours. |
