Atropine Sulfate Injection（Atropine Sulfate）
atropine sulfate - Drug Summary
CLASSES
Anticholinergics for Cardiac conditions
Belladonna and Derivatives
Mydriatics and Cycloplegics
DEA CLASS
Rx
DESCRIPTION
Natural tertiary amine extracted from belladonna alkaloid
Consists of a racemic mixture of both d- and l-hyoscyamine
Used systemically for many purposes, including symptomatic bradycardia; reduces secretions prior to surgery; also applied topically to the eye to produce mydriasis
COMMON BRAND NAMES
Atropine Care, Atropisol, Isopto Atropine, Ocu-Tropine
HOW SUPPLIED
Atropine/Atropine Care/Atropine Sulfate/Atropisol/Isopto Atropine Ophthalmic Sol: 1%
Atropine/Atropine Care/Atropine Sulfate/Ocu-Tropine Ophthalmic Ointment: 1%
Atropine/Atropine Sulfate Intramuscular Inj Sol: 0.05mg, 0.1mg, 0.4mg, 0.5mL, 1mL, 1mg
Atropine/Atropine Sulfate Intravenous Inj Sol: 0.05mg, 0.1mg, 0.4mg, 0.5mL, 1mL, 1mg
Atropine/Atropine Sulfate Subcutaneous Inj Sol: 0.05mg, 0.1mg, 0.4mg, 0.5mL, 1mL, 1mg
DOSAGE & INDICATIONS
For the treatment of bradyasystolic cardiac arrest.
Intravenous or Intraosseous† Dosage
Adults
1 mg IV every 3 to 5 minutes as needed up to Max: 3 mg. Clinical practice guidelines do not include atropine due to unlikely therapeutic benefit in pulseless electrical activity (PEA) or asystole. Previously, could be given via the intraosseous route when IV access is not available.
Infants, Children, and Adolescents
0.01 to 0.03 mg/kg/dose IV. Atropine is not included in the PALS algorithm for cardiac arrest and is no longer routinely recommended due to unlikely therapeutic benefit in PEA or asystole. The previous PALS dosage recommendation was 0.02 mg/kg/dose IV (minimum dose of 0.1 mg; Max: 0.5 mg) with a second dose administered if indicated. The same dosage may be given via the intraosseous route when IV access is not available. Do not interrupt CPR to administer drug therapy. Cardiac arrest in children is uncommon and usually results from progressive respiratory failure or shock (e.g., asphyxial arrest) rather than from cardiac etiology.
Neonates
0.01 to 0.03 mg/kg/dose IV. Atropine is not included in the PALS algorithm for cardiac arrest and is no longer routinely recommended due to unlikely therapeutic benefit in PEA or asystole. The previous PALS dosage recommendation was 0.02 mg/kg/dose IV with a second dose administered if indicated. When using atropine, PALS recommends a minimum single dose of 0.1 mg, however, some feel this dose may be excessive in very small neonates since the total dosage would be greater than 0.02 mg/kg. The same dosage may be given via the intraosseous route when IV access is not available. Do not interrupt CPR to administer drug therapy.
Endotracheal Dosage
NOTE: Endotracheal (ET) administration may be unreliable; use only if access to IV or intraosseous routes are not available.
Adults
1 to 2 mg ET (diluted in no more than 10 mL of 0.9% Sodium Chloride Injection or Sterile Water for Injection). Clinical practice guidelines do not include atropine due to unlikely therapeutic benefit in pulseless electrical activity (PEA) or asystole.
Neonates, Infants, Children, and Adolescents
Atropine is not included in the PALS algorithm for cardiac arrest and is no longer routinely recommended due to unlikely therapeutic benefit in PEA or asystole. The previous PALS dosage recommendation was 0.04 to 0.06 mg/kg/do