Common side effects of INCIVEK in combination with peginterferon alfa and ribavirin include:

• itching
• nausea
• diarrhea
• vomiting
• anal or rectal problems, including:
  • hemorrhoids
  • discomfort or burning around or near the anus
  • itching around or near the anus
• taste changes
• tiredness

Tell your healthcare provider about any side effect that bothers you or does not go away.

These are not all the possible side effects of INCIVEK. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to Vertex Pharmaceuticals Incorporated at 1-877-824-4281.

How should I store INCIVEK?

• Store INCIVEK tablets at room temperature between 59ºF to 86ºF (15°C to 30°C).

Keep INCIVEK and all medicines out of the reach of children.

General information about INCIVEK

It is not known if treatment with INCIVEK will prevent you from infecting another person with the hepatitis C virus during treatment or if you do not respond to treatment.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use INCIVEK for a condition for which it was not prescribed. Do not give INCIVEK to other people, even if they have the same symptoms or condition you have. It may harm them.

This Medication Guide summarizes the most important information about INCIVEK. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about INCIVEK that is written for healthcare professionals.

For more information, go to www.incivek.com or call 1-877-824-4281.

What are the ingredients in INCIVEK?

Active ingredient: telaprevir

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, D&C Red No. 40, dibasic calcium phosphate (anhydrous), FD&C Blue No. 2, hypromellose acetate succinate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, sodium lauryl sulfate, sodium stearyl fumarate, talc, and titanium dioxide.

This Medication Guide has been approved by the U.S. Food and Drug Administration.