|
15 |
↓ |
0.65
(0.60; 0.71) |
0.64
(0.58; 0.70) |
0.60
(0.54; 0.67) |
|
Midazolam (iv) |
0.5 mg iv single dose |
750 mg q8h for 9 days |
22 |
↑ |
1.02
(0.8; 1.31) |
3.40
(3.04; 3.79) |
NA |
|
Midazolam (oral) |
2 mg oral single dose |
750 mg q8h for 11 days |
21 |
↑ |
2.86
(2.52; 3.25) |
8.96
(7.75; 10.35) |
NA |
|
Norethindrone (NE), co-administered with EE |
0.035 mg qd EE/ 0.5 mg
qd NE for 21 days |
750 mg q8h for 7 days |
24 |
↔ |
0.85
(0.81; 0.89) |
0.89
(0.86; 0.93) |
0.94
(0.87; 1.0) |
|
Tacrolimus |
2 mg single dose when administered alone; 0.5 mg single dose when co-administered with telaprevir (D8) |
750 mg q8h for 13 days |
9 |
↑ |
2.34
(1.68; 3.25)
Dose norm.: 9.35
(6.73; 13.0) |
17.6
(13.2; 23.3)
Dose norm.: 70.3
(52.9; 93.4) |
NA |
|
Zolpidem |
5 mg single dose |
750 mg q8h for 10 days |
19 |
↓ |
0.58
(0.52; 0.66) |
0.53
(0.45; 0.64) |
NA |
|
Anti-HIV Drugs |
|
Atazanavir (ATV), boosted with ritonavir (rtv) |
300 mg ATV/ 100 mg rtv qd for 20 days |
750 mg q8h for 10 days |
7 |
↔ |
0.85
(0.73; 0.98) |
1.17
(0.97; 1.43) |
1.85
(1.40; 2.44) |
|
Darunavir (DRV), boosted with ritonavir (rtv) |
600 mg DRV/ 100 mg rtv bid for 20 days |
750 mg q8h for 10 days |
11 (N=14 for Cmax) |
↓ |
0.60
(0.56; 0.64) |
0.60
(0.57; 0.63) |
0.58
(0.52; 0.64) |
|
600 mg DRV/ 100 mg rtv bid for 24 days |
1125 mg q12h for 4 days |
15 |
↓ |
0.53
(0.47; 0.59) |
0.49
(0.43; 0.55) |
0.42
(0.35; 0.51) |
|
Efavirenz |
600 mg qd for 20 days |
750 mg q8h for 10 days |
21 |
↔ |
0.84
(0.76; 0.93) |
0.93
(0.87; 0.98) |
0.98
(0.94; 1.02) |
|
Efavirenz (EFV), co-administered with tenofovir disoproxil fumarate (TDF) |
600 mg EFV /300 mg TDF qd for 7 days |
