|
TOP
|
|
INCIVEK(telaprevir)tablet, film coated(二十三)
|
n of the change in PK
|
|
Alprazolam |
0.5 mg single dose |
750 mg q8h for 10 days |
17 |
↑ |
0.97
(0.92; 1.03) |
1.35
(1.23; 1.49) |
NA |
|
Amlodipine |
5 mg single dose |
750 mg q8h for 7 days |
19 |
↑ |
1.27
(1.21; 1.33) |
2.79
(2.58; 3.01) |
NA |
|
Atorvastatin |
20 mg single dose |
750 mg q8h for 7 days |
19 |
↑ |
10.60
(8.74; 12.85) |
7.88
(6.84; 9.07) |
NA |
|
Cyclosporine A (CsA) |
100 mg single dose when administered alone; 10 mg single dose when co-administered with telaprevir (D8) |
750 mg q8h for 11 days |
9 |
↑ |
0.13
(0.11; 0.16)
Dose norm.: 1.32
(1.08; 1.60) |
0.46
(0.39; 0.55)
Dose norm.: 4.64
(3.90; 5.51) |
NA |
|
Digoxin |
2 mg single dose |
750 mg q8h for 11 days |
20 |
↑ |
1.50
(1.36; 1.65) |
1.85
(1.70; 2.00) |
NA |
|
Escitalopram |
10 mg qd, for 7 days |
750 mg q8h for 14 days |
13 |
↓ |
0.70
(0.65; 0.76) |
0.65
(0.60; 0.70) |
0.58
(0.52; 0.64) |
|
Ethinyl estradiol (EE), co-administered with norethindrone (NE) |
0.035 mg qd EE/ 0.5 mg
qd NE for 21 days |
750 mg q8h for 21 days |
24 |
↓ |
0.74
(0.68; 0.80) |
0.72
(0.69; 0.75) |
0.67
(0.63; 0.71) |
|
Ketoconazole |
400 mg single dose |
1250 mg q8h for 4 doses |
81 |
↑ |
1.23
(1.14; 1.33) |
1.46
(1.35; 1.58) |
NA |
|
200 mg single dose |
1250 mg q8h for 4 doses |
28 |
↑ |
1.75
(1.51; 2.03) |
2.25
(1.93; 2.61) |
NA |
|
R-Methadone |
Methadone maintenance therapy (40 to 120 mg/daily) |
750 mg q8h for 7 days |
15 |
↓ |
0.71
(0.66; 0.76) |
0.71
(0.66; 0.76) |
0.69
(0.64; 0.75) |
|
S-Methadone |
Methadone maintenance therapy (40 to 120 mg/daily) |
750 mg q8h for 7 days |
|
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