|
enz |
600 mg qd for 20 days |
750 mg q8h for 10 days |
21 |
↓ |
0.91
(0.82; 1.02) |
0.74
(0.65; 0.84) |
0.53
(0.44; 0.65) |
|
Fosamprenavir (fAPV)/ ritonavir (rtv) |
700 mg fAPV/ 100 mg rtv bid for 20 days |
750 mg q8h for 10 days |
18 |
↓ |
0.67
(0.63; 0.71) |
0.68
(0.63; 0.72) |
0.70
(0.64; 0.77) |
|
Lopinavir (LPV)/ritonavir (rtv) |
400 mg LPV/ 100 mg rtv bid for 20 days |
750 mg q8h for 10 days |
12 |
↓ |
0.47
(0.41; 0.52) |
0.46
(0.41; 0.52) |
0.48
(0.40; 0.56) |
|
Ritonavir |
100 mg single dose |
750 mg single dose |
14 |
↑ |
1.30
(1.15; 1.47) |
2.00
(1.72; 2.33) |
NA |
|
Ritonavir |
100 mg q12h for 14 days |
750 mg q12h for 14 days |
5 |
↓ |
0.85
(0.63; 1.13) |
0.76‡,§
(0.60; 0.97) |
0.68
(0.57; 0.82) |
|
Tenofovir disoproxil fumarate (TDF) |
300 mg qd TDF for 7 days |
750 mg q8h for 7 days |
16 |
↔ |
1.01
(0.96; 1.05) |
1.00
(0.94; 1.07) |
1.03
(0.93; 1.14) |
|
Tenofovir disoproxil fumarate (TDF) and efavirenz (EFV) |
600 mg EFV /300 mg TDF qd for 7 days |
1125 mg q8h for 7 days |
15 |
↓ |
0.86§
(0.76; 0.97) |
0.82§
(0.73; 0.92) |
0.75§
(0.66; 0.86) |
|
600 mg EFV /300 mg TDF qd for 7 days |
1500 mg q12h for 7 days |
16 |
↓ |
0.97§
(0.88; 1.06) |
0.80‡,§
(0.73; 0.88) |
0.52§
(0.42; 0.64) |
