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TOP
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INCIVEK(telaprevir)tablet, film coated(二十一)
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ir PK†
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LS Mean Ratio (90% CI) of Telaprevir PK With/Without Co-administered Drug |
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Drug |
Telaprevir |
Cmax |
AUC or Cavg,ss‡ |
Cmin |
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NA: not available/ not applicable; N = Number of subjects with data; qd = once daily; bid = twice daily; q8h = every 8 hours; q12h = every 12 hours |
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Escitalopram |
10 mg qd for 7 days |
750 mg q8h for 14 days |
13 |
↔ |
1.00
(0.95; 1.05) |
0.93
(0.89; 0.97) |
0.91
(0.86; 0.97) |
|
Esomeprazole |
40 mg qd for 6 days |
750 mg single dose |
24 |
↔ |
0.95
(0.86; 1.06) |
0.98
(0.91; 1.05) |
NA |
|
Ketoconazole |
Ketoconazole
400 mg single dose |
750 mg single dose |
17 |
↑ |
1.24
(1.10; 1.41) |
1.62
(1.45; 1.81) |
NA |
|
Oral Contraceptive |
Norethindrone/ ethinyl estradiol 0.5 mg/0.035 mg qd for 21 days |
750 mg q8h for 21 days |
23 |
↔ |
1.00
(0.93; 1.07) |
0.99
(0.93; 1.05) |
1.00
(0.93; 1.08) |
|
Rifampin |
600 mg qd for 8 days |
750 mg single dose |
16 |
↓ |
0.14
(0.11; 0.18) |
0.08
(0.07; 0.11) |
NA |
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Anti-HIV Drugs |
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Atazanavir (ATV)/ritonavir (rtv) |
300 mg ATV/ 100 mg rtv qd for 20 days |
750 mg q8h for 10 days |
14 |
↓ |
0.79
(0.74; 0.84) |
0.80
(0.76; 0.85) |
0.85
(0.75; 0.98) |
|
Darunavir (DRV)/ritonavir (rtv) |
600 mg DRV/ 100 mg rtv bid for 20 days |
750 mg q8h for 10 days |
11 (N=14 for Cmax) |
↓ |
0.64
(0.61; 0.67) |
0.65
(0.61; 0.69) |
0.68
(0.63; 0.74) |
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Efavir |
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