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INCIVEK(telaprevir)tablet, film coated(十一)
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ANTIARRHYTHMICS |
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lidocaine (systemic), amiodarone, bepridil, flecainide, propafenone, quinidine |
↑ antiarrhythmics |
Co-administration with telaprevir has the potential to produce serious and/or life-threatening adverse events and has not been studied. Caution is warranted and clinical monitoring is recommended when co-administered with telaprevir. |
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digoxin* |
↑ digoxin |
Concentrations of digoxin were increased when co-administered with telaprevir. The lowest dose of digoxin should be initially prescribed. The serum digoxin concentrations should be monitored and used for titration of digoxin dose to obtain the desired clinical effect. |
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ANTIBACTERIALS |
clarithromycin
erythromycin
telithromycin |
↑ telaprevir
↑ antibacterials |
Concentrations of both telaprevir and the antibacterial may be increased during co-administration. Caution is warranted and clinical monitoring is recommended when co-administered with telaprevir. QT interval prolongation and Torsade de Pointes have been reported with clarithromycin and erythromycin. QT interval prolongation has been reported with telithromycin. |
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ANTICOAGULANT |
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warfarin |
↑ or ↓ warfarin |
Concentrations of warfarin may be altered when co-administered with telaprevir. The international normalized ratio (INR) should be monitored when warfarin is co-administered with telaprevir. |
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ANTICONVULSANTS |
carbamazepine
phenobarbital
phenytoin |
↓ telaprevir
↑ carbamazepine
↑ or ↓ phenytoin
↑ or ↓ phenobarbital |
Concentrations of the anticonvulsant may be altered and concentrations of telaprevir may be decreased. Caution should be used when prescribing carbamazepine, phenobarbital, and phenytoin.
Telaprevir may be less effective in patients taking these agents concomitantly.
Clinical or laboratory monitoring of carbamazepine, phenobarbital, and phenytoin concentrations and dose titration are recommended to achieve the desired clinical response. |
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ANTIDEPRESSANTS |
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escitalopram* |
↔ telaprevir
↓ escitalopram |
Concentrations of escitalopram were decreased when co-administered with telaprevir. Selective serotonin reuptake inhibitors such as escitalopram have a wide therapeutic index, but doses may need to be adjusted when combined with telaprevir. |
desipramine
trazodone |
↑ desipramine
↑ trazodone |
Concomitant use of trazodone or desipramine and telaprevir may increase plasma concentrations of trazodone or desipramine which may lead to adverse events such as nausea, dizziness, hypotension and syncope. If trazodone or desipramine is used with telaprevir, the combination should be used with caution and a lower dose of trazodone or desipramine should be considered. |
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