ours may also be considered empirically as part of broad spectrum therapy for mixed infections when administered with metronidazole or clindamycin. Surgical intervention is the primary therapeutic intervention. Antibiotic therapy should be administered until further debridement is not necessary, the patient has improved clinically, and fever has been absent for 48 to 72 hours.
Adolescents, Children, and Infants
50 mg/kg/dose IV every 6 hours (Max: 2 g/dose), in combination with metronidazole or clindamycin, is recommended in clinical practice guidelines.
For the treatment of animal bite wounds.
Intravenous dosage
Adults
1 to 2 g IV every 6 to 8 hours with an anaerobic agent (clindamycin or metronidazole). In setting of a cat or dog bite, clinical practice guidelines also recommend pre-emptive antimicrobial therapy for 3 to 5 days for patients who are immunocompromised, asplenic, have advanced liver disease, have edema of the bite area, have moderate to severe injuries, particularly of the hand or face, or have penetrating injuries to the periosteum or joint capsule.
Intravenous or Intramuscular dosage
Adults
1 g IV or IM every 12 hours for uncomplicated infections; 1 to 2 g IV or IM every 8 hours for moderate to severe infections; 2 g IV every 6 to 8 hours for severe infections, and 2 g IV every 4 hours for life-threatening infections. The maximum dosage is 12 g/day.
Adolescents and Children weighing 50 kg or more
1 g IV or IM every 12 hours for uncomplicated infections; 1 to 2 g IV or IM every 8 hours for moderate to severe infections; 2 g IV every 6 to 8 hours for severe infections, and 2 g IV every 4 hours for life-threatening infections. The maximum dosage is 12 g/day.
Children weighing less than 50 kg and Infants
50 to 180 mg/kg/day IV or IM divided every 6 to 8 hours (Max: 2 g/dose); use higher doses for more severe infections. 200 to 225 mg/kg/day IV or IM divided every 4 to 6 hours (Max: 12 g/day) is recommended by the American Academy of Pediatrics (AAP) for severe infections.
Premature and Term Neonates older than 7 days
50 mg/kg/dose IV or IM every 8 to 12 hours for neonates weighing 2 kg or less and 50 mg/kg/dose IV or IM every 8 hours for neonates weighing more than 2 kg is recommended by the American Academy of Pediatrics (AAP). The FDA-approved labeling recommends 50 mg/kg/dose IV every 8 hours regardless of weight.
Premature and Term Neonates 0 to 7 days
50 mg/kg/dose IV or IM every 12 hours.
For the treatment of bone and joint infections.
Intravenous or Intramuscular dosage
Adults
1 to 2 g IV or IM every 8 hours for moderate to severe infections; 2 g IV every 6 to 8 hours for severe infections, and 2 g IV every 4 hours for life-threatening infections. The maximum dosage is 12 g/day.
Adolescents and Children weighing 50 kg or more
1 to 2 g IV or IM every 8 hours for moderate to severe infections; 2 g IV every 6 to 8 hours for severe infections, and 2 g IV every 4 hours for life-threatening infections. The maximum dosage is 12 g/day.
Children weighing less than 50 kg and Infants
50 to 180 mg/kg/day IV or IM divided every 6 to 8 hours (Max: 2 g/dose); use higher doses for more severe infections. 200 to 225 mg/kg/day IV or IM divided every 4 to 6 hours (Max: 12 g/day) is recommended by The American Academy of Pediatrics (AAP) for severe infections.
Premature and Term Neonates older than 7 days
50 mg/kg/dose IV or IM every 8 to 12 hours for neonates weighing 2 kg or less and 50 mg/kg/dose IV or IM every 8 hours for neonates weighing more than 2 kg is recommended by the American Academy of Pediatrics (AA |
