1000 mg/day). The Infectious Diseases Society of America (IDSA) does not recommend cefuroxime for empiric use.
For the treatment of pneumonia, including community-acquired pneumonia (CAP).
Intravenous dosage
Adults
0.75 to 1.5 g IV every 8 hours. For life-threatening infections or infections due to less susceptible organisms, 1.5 g IV every 6 hours may be required.
Infants 3 to 11 months, Children, and Adolescents
50 to 100 mg/kg/day IV divided every 6 to 8 hours (Max: 6 g/day), with the higher dose of 100 mg/kg/day recommended for more severe or serious infections, is the FDA-approved dosage. 75 to 100 mg/kg/day IV divided every 8 hours (Max: 4.5 g/day) for mild-to-moderate infections and 100 to 200 mg/kg/day IV divided every 6 to 8 hours (Max: 6 g/day) for severe infections is the general pediatric dosing recommended by the American Academy of Pediatrics (AAP). Higher doses (i.e., 150 mg/kg/day) are generally recommended for pneumonia.
Infants 1 to 2 months†
75 to 100 mg/kg/day IV divided every 8 hours for mild-to-moderate infections and 100 to 200 mg/kg/day IV divided every 6 to 8 hours for severe infections is the general pediatric dosing recommended by the American Academy of Pediatrics (AAP). Higher doses (i.e., 150 mg/kg/day) are generally recommended for pneumonia. 75 mg/kg/day IV divided every 8 hours was effectively used in an open-label study of 100 infants and children (1 month and older) with pneumonia.
Neonates 8 days and older weighing more than 2000 g†
50 mg/kg/dose IV every 8 hours is the general dosing recommended by the American Academy of Pediatrics (AAP).
Neonates 8 days and older weighing 2000 g or less†
50 mg/kg/dose IV every 8 to 12 hours is the general dosing recommended by the American Academy of Pediatrics (AAP).
Neonates 0 to 7 days†
50 mg/kg/dose IV every 12 hours is the general dosing recommended by the American Academy of Pediatrics (AAP).
Intramuscular dosage
Adults
0.75 g IM every 8 hours.
Infants 3 to 11 months, Children, and Adolescents
50 to 100 mg/kg/day IM divided every 6 to 8 hours (Max: 6 g/day), with the higher dose of 100 mg/kg/day recommended for more severe or serious infections, is the FDA-approved dosage. 75 to 100 mg/kg/day IM divided every 8 hours (Max: 4.5 g/day) for mild-to-moderate infections and 100 to 200 mg/kg/day IM divided every 6 to 8 hours (Max: 6 g/day) for severe infections is the general pediatric dosing recommended by the American Academy of Pediatrics (AAP). Higher doses (i.e., 150 mg/kg/day) are generally recommended for pneumonia.
Infants 1 to 2 months†
75 to 100 mg/kg/day IM divided every 8 hours for mild-to-moderate infections and 100 to 200 mg/kg/day IM divided every 6 to 8 hours for severe infections is the general pediatric dosing recommended by the American Academy of Pediatrics (AAP). Higher doses (i.e., 150 mg/kg/day) are generally recommended for pneumonia. 75 mg/kg/day IM divided every 8 hours was effectively used in an open study of 100 infants and children (1 month and older) with pneumonia.
Neonates 8 days and older weighing more than 2000 g†
50 mg/kg/dose IM every 8 hours is the general dosing recommended by the American Academy of Pediatrics (AAP).
Neonates 8 days and older weighing 2000 g or less†
50 mg/kg/dose IM every 8 to 12 hours is the general dosing recommended by the American Academy of Pediatrics (AAP). In general, IM administration of drugs in very low birth weight premature neonates is not practical due to small muscle mass |
