g/day IV in equally divided doses every 6 to 8 hours (Max: 6 g/day).
Intramuscular dosage
Infants 3 months and older, Children, and Adolescents
100 mg/kg/day IM in equally divided doses every 6 to 8 hours (Max: 6 g/day).
For the treatment of meningitis.
Intravenous dosage
Adults
1.5 g IV every 6 hours or 3 g IV every 8 hours (Max: 9 g/day).
Infants 3 months and older, Children, and Adolescents
200 to 240 mg/kg/day IV in equally divided doses every 6 to 8 hours (Max: 9 g/day).
For surgical infection prophylaxis.
for ophthalmic surgical infection prophylaxis†.
Intraocular dosage
Adults
1 mg by intracameral injection is optional at the end of the procedure. Perioperative antisepsis with povidone-iodine is recommended. The necessity of continuing topical antimicrobials postoperatively has not been established.
Intravenous or Intramuscular dosage
Adults
1.5 g IV or IM within 30 to 60 minutes prior to the surgical incision. For lengthy operations, additional doses of 750 mg IV or IM may be given during the procedure and postoperatively every 8 hours. For open heart surgery, 1.5 g IV every 12 hours for 6 g total dose. Intraoperative redosing 4 hours from the first preoperative dose and a duration of prophylaxis less than 24 hours for most procedures are recommended by clinical practice guidelines. A longer prophylaxis duration of 48 hours for certain cardiothoracic procedures is controversial. Cefuroxime is FDA-approved for clean-contaminated or potentially contaminated procedures. Clinical practice guidelines recommend cefuroxime for cardiac or clean head and neck (with prosthesis) procedures and as an alternate therapy for urogynecology procedures. Cefuroxime is also recommended in combination with metronidazole for clean-contaminated head and neck procedures.
Infants†, Children†, and Adolescents†
50 mg/kg IV or IM as a single dose (Max: 1.5 g/dose) within 60 minutes prior to the surgical incision. Intraoperative redosing 4 hours from the first preoperative dose and a duration of prophylaxis less than 24 hours for most procedures are recommended by clinical practice guidelines. A longer prophylaxis duration of 48 hours for certain cardiothoracic procedures is controversial. Clinical practice guidelines recommend cefuroxime for cardiac or clean head and neck (with prosthesis) procedures. Cefuroxime is also recommended in combination with metronidazole for clean-contaminated head and neck procedures.
For the treatment of tonsillitis.
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Oral dosage (tablets)
Adults and Adolescents
250 mg PO every 12 hours for 10 days.
Oral dosage (suspension)
Infants 3 months and older and Children
20 mg/kg/day PO divided into 2 doses for 10 days (Max: 500 mg/day).
For the treatment of sinusitis.
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Oral dosage (tablets)
Adults and Adolescents
250 mg PO twice daily for 10 days. The Infectious Diseases Society of America (IDSA) does not recommend cefuroxime for empiric use.
Children (who can swallow tablets whole)
250 mg PO twice daily for 10 days. The Infectious Diseases Society of America (IDSA) does not recommend cefuroxime for empiric use.
Oral dosage (suspension)
Infants 3 months and older and Children
30 mg/kg PO divided into 2 doses for 10 days (Max: |
