50 to 100 mg/kg/day IV in equally divided doses every 6 to 8 hours (Max: 6g/day).
Intramuscular dosage
Adults
0.75 IM every 8 hours.
Infans 3 months and older, Children, and Adolescents
50 to 100 mg/kg/day IM in equally divided doses every 6 to 8 hours (Max: 6g/day).
For the treatment of bone and joint infections.
Intravenous dosage
Adults
1.5 g IV every 8 hours. For life-threatening infections or infections due to less susceptible organisms, 1.5 g IV every 6 hours may be required.
Infants 3 months or older, Children, and Adolescents
150 mg/kg/day IV in equally divided doses every 8 hours (Max: 6 g/day).
Intramuscular dosage
Infants 3 months or older, Children, and Adolescents
150 mg/kg/day IM in equally divided doses every 8 hours (Max: 6 g/day).
For the treatment of pharyngitis.
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Oral dosage (tablets)
Adults and Adolescents
250 mg PO every 12 hours for 10 days. Guidelines do not recommended cefuroxime for routine therapy for Group A Streptococcal pharyngitis therapy to prevent rheumatic fever.
Oral dosage (suspension)
Infants 3 months and older and Children
20 mg/kg/day PO divided into 2 doses for 10 days (Max: 500 mg/day). Guidelines do not recommended cefuroxime for routine therapy for Group A Streptococcal pharyngitis therapy to prevent rheumatic fever.
For the treatment of gonorrhea.
For cervicitis or urethritis due to N. gonorrhoeae or rectal gonorrhea in females or urethritis in males.
Oral dosage (tablets)
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram per milligram basis.
Adults and Adolescents
Due to resistance, the CDC does not recommend cefuroxime for gonorrhea. The manufacturer recommends 1 g PO as a single dose.
Intramuscular dosage
Adults and Adolescents
The CDC does not recommend IM cefuroxime. The FDA-approved dose is 1.5 g IM as a single dose at 2 different sites in combination with probenecid.
For disseminated gonococcal infection due to N. gonorrhoeae.
Intravenous dosage
Adults and Adolescents
The CDC does not recommend cefuroxime for gonorrhea. The manufacturer recommends 750 mg IV every 8 hours. In severe or complicated infections, a dosage of 1.5 g IV every 8 hours is recommended.
For the treatment of early Lyme disease (erythema migrans).
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Oral dosage (tablets)
Adults and Adolescents
500 mg PO every 12 hours for 20 days.
Oral dosage (suspension)†
Children†
The American Academy of Pediatrics (AAP) recommends 30 mg/kg/day PO in 2 divided doses (Max: 1000 mg/day) or 1000 mg/day for 14 to 21 days.
For the treatment of acute otitis media.
NOTE: Oral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis.
Oral dosage (tablets)
Children (who can swallow whole tablets)
250 mg PO every 12 hours for 10 days.
Oral dosage (suspension)
Infants 3 months and older and Children
30 mg/kg/day PO divided into 2 doses for 10 days (Max: 1000 mg/day).
For the treatment of septicemia.
Intravenous dosage
Adults
1.5 g IV every 8 hours. For life-threatening infections or infections due to less susceptible organisms, 1.5 g IV every 6 hours may be required.
Infants 3 months and older, Children, and Adolescents
100 mg/k |
