um concentrations of approximately 2 mcg/mL or more were maintained for 5.3 hours and >= 8 hours, respectively. There was no evidence of accumulation of cefuroxime in the serum following IV administration of 1.5 g doses every 8 hours to normal adult volunteers. The serum half-life after IV injection is approximately 80 minutes. Approximately 89% of a dose of cefuroxime is excreted by the kidneys over an 8-hour period, resulting in high urinary concentrations. IV doses of 750 mg and 1.5 g produced urinary levels averaging 1150 and 2500 mcg/mL, respectively, during the first 8-hour period.
Intramuscular Route
In adults, peak serum levels of cefuroxime sodium occurs at roughly 45 minutes (range: 15—60 minutes) following intramuscular (IM) injection of a 750 mg dose; the mean peak serum concentration was 27 mcg/mL. The serum half-life after IM injection is approximately 80 minutes. Approximately 89% of a dose of cefuroxime is excreted by the kidneys over an 8-hour period, resulting in high urinary concentrations. Urinary concentrations following IM dosing averaged 1300 mcg/mL during the first 8 hours. |
