an prior to taking any of these medications while receiving LUVOX CR Capsule therapy.
• Serotonergic drugs, including triptans, tramadol, and tryptophan: See WARNINGS AND PRECAUTIONS (5.2).
• Antipsychotic agents, including clozapine: See WARNINGS AND PRECAUTIONS (5.2, 5.9).
• ertain benzodiazepines: See WARNINGS AND PRECAUTIONS (5.9).
• Methadone: See WARNINGS AND PRECAUTIONS (5.9).
• Mexiletine: See WARNINGS AND PRECAUTIONS (5.9).
• Theophylline: See WARNINGS AND PRECAUTIONS (5.9).
• Warfarin and other drugs that interfere with hemostasis: Patients should be cautioned about the concomitant use of fluvoxamine and NSAIDs, aspirin, or other drugs that affect coagulation since the combined use of psychotropic drugs that interfere with serotonin reuptake and these agents has been associated with an increased risk of bleeding (see WARNINGS AND PRECAUTIONS [5.9, 5.11]).
• Diuretics: See WARNINGS AND PRECAUTIONS (5.14).
In addition, patients should be advised to notify their physicians if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for clinically important interactions with LUVOX CR Capsules.
17.4 Abnormal Bleeding Patients should be advised that LUVOX CR Capsules may increase the risk of bleeding events, which have ranged from ecchymoses, hematomas, epistaxis, and petechiae to life-threatening hemorrhages. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anticoagulants may add to this risk (see WARNINGS AND PRECAUTIONS [5.8, 5.10]).
17.5 Angle Closure GlaucomaPatients should be advised that taking Luvox CR can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle closure glaucoma. Pre-existing glaucoma is almost always open-angle glaucoma because angle closure glaucoma, when diagnosed can be treated definitively with iridectomy. Open-angle glaucoma is not a risk factor for angle closure glaucoma. Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure (e.g., iridectomy), if they are susceptible (see WARNINGS AND PRECAUTIONS [5.3]).
17.6 Interference with Cognitive or Motor Performance Since any psychoactive drug may impair judgment, thinking, or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are certain that LUVOX CR Capsules therapy does not adversely affect their ability to engage in such activities.
17.7 Pregnancy Patients should be advised to notify their physicians if they become pregnant or intend to become pregnant during therapy with LUVOX CR Capsules (see USE IN SPECIFIC POPULATIONS [8.1]).
17.8 Nursing Patients receiving LUVOX CR Capsules should be advised to notify their physicians if they are breast-feeding an infant. (See USE IN SPECIFIC POPULATIONS-Nursing Mothers [8.3]).
17.9 Alcohol As with other psychotropic medications, patients should be advised to avoid alcohol while taking LUVOX CR Capsules.
17.10 Allergic Reactions Patients should be advised to notify their physicians if they develop a rash, hives, or a related allergic phenomenon during therapy with LUVOX CR Capsules.
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