N=130
N=79
N=44
Response Rates (%)
eva luable CR
84
18
85
58
PR
6
24
4
28
Intent-to-Treat
N=170
N=170
CR
68
14
PR
5
18
Median Time to Response (months)
CR
6.6
11.5
6.0
4.2
PR
4.0
6.2
5.8
—
Median Duration of Response (months)
CR
NR
8.3
NR
>7.7c (CALGB)
>15.2c (MDA)
PR
NR
15.2
NR
—
% Estimated to be in Response After 24 Months
CR
76
16
85
—
PR
50
21
—
—
Median Time to Recovery (days)
ANC (1500/mm3)
70
106
—
—
Platelets (100,000/mm3)
22
36
—
—
NR = Not reached by Kaplan-Meier method; ANC = Absolute neutrophil count.
aeva luable patients
bPatients either refractory to, or intolerant of, IFN
cKaplan-Meier estimate
The results show that frontline patients treated with Nipent achieved a significantly higher rate of response than those treated with IFN. The time to recovery of neutrophil and platelet counts was shorter with Nipent treatment and the estimated duration of response was longer. The response rate in IFN-refractory p
