e the causative organisms and their susceptibility to oxacillin should always be performed. Duration of therapy varies with the type of severity of infection as well as the overall condition of the patient; therefore, it should be determined by the clinical and bacteriological response of the patient. In severe staphylococcal infections, therapy with oxacillin should be continued for at least 14 days. Therapy should be continued for at least 48 hours after the patient has become afebrile, asymptomatic, and cultures are negative. Treatment of endocarditis and osteomyelitis may require a longer duration of therapy.
Concurrent administration of oxacillin and probenecid increases and prolongs serum penicillin levels. Probenecid decreases the apparent volume of distribution and slows the rate of excretion by competitively inhibiting renal tubular secretion of penicillin. Penicillin-probenecid therapy is generally limited to those infections where very high serum levels of penicillin are necessary.
Oral preparations of the penicillinase-resistant penicillins should not be used as initial therapy in serious, life-threatening infections (see PRECAUTIONS-General). Oral therapy with the penicillinase-resistant penicillins may be used to follow-up the previous use of a parenteral agent as soon as the clinical condition warrants. For intramuscular gluteal injections, care should be taken to avoid sciatic nerve injury.
With intravenous administration, particularly in elderly patients, care should be taken because of the possibility of thrombophlebitis.
RECOMMENDED DOSAGES FOR OXACILLIN FOR INJECTION, USP
|
Drug |
Adults |
Infants and Children
<40 kg (88 lbs) |
Other
Recommendations |
|
Oxacillin |
250 to 500 mg IM or
IV every 4 to 6 hours
(mild to moderate
infections) |
50 mg/kg/day IM or
IV in equally divided
doses every 6 hours
(mild to moderate
infections) |
|
|
Oxacillin |
1 gram IM or IV
every 4 to 6 hours
(severe infections) |
100 mg/kg/day IM
or IV in equally
divided doses every
4 to 6 hours
(severe infections) |
Premature and
Neonates 25 mg/kg/day
IM or IV |
Directions for Use
For Intramuscular Use
Use Sterile Water for Injection, USP. Add 5.7 mL to the 1 gram vial and 11.5 mL to the 2 gram vial. Shake well until a clear solution is obtained. After reconstitution, vials will contain 250 mg of active drug per 1.5 mL of solution. The reconstituted solution is stable for 3 days at 70°F or for one week under refrigeration (40°F).
For Direct Intravenous Use
Use Sterile Water for Injection, USP or Sodium Chloride Injection, USP. Add 10 mL to the 1 gram vial and 20 mL to the 2 gram vial. Withdraw the entire contents and administer slowly over a period of approximately 10 minutes.
For Administration by Intravenous Drip
Reconstitute as directed above (For Direct Intravenous Use) prior to diluting with Intravenous Solution.
STABILITY PERIODS FOR OXACILLIN FOR INJECTION, USP
|
Concentration mg/mL |
Sterile
Water for
Injection |
Sodium Chloride Injection 0.9% |
M/6 Molar
Sodium
Lactate
Injection |
Dex |
|
