ce.
For a more comfortable injection, wait 15 to 30 minutes to allow the autoinjector to reach room temperature. Do not remove the white needle cap while allowing it to reach room temperature. Do not warm ENBREL® in any other way (for example, do not warm it in a microwave or in hot water).
Wash your hands thoroughly.
Do not remove the white needle cap from the autoinjector until you are ready to inject.
Choosing and Preparing an Injection Site
Choose an Injection Site
The injection site must be firm for the autoinjector to work properly. The preferred injection site for ENBREL® using a prefilled SureClick™ autoinjector is the front of the thigh.
Rotate Injection Location
Rotate the site for each injection. Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid areas with stretch marks.
Patients with Psoriasis
If you have psoriasis, you should try not to inject directly into any raised, thick, red, or scaly skin patches or lesions.
Instructions for Preferred Injection Site
The front of the thigh is the preferred injection site.
Instructions for Alternate Injection Sites
When using alternate injection sites, it is particularly important to create enough firmness on the site to be able to successfully complete the injection.
Stretch technique
Make sure the skin under and around the prefilled autoinjector is firm and taut to provide enough resistance to fully retract the safety guard and unlock the prefilled autoinjector.
You can use the abdomen, except for the two-inch area right around the navel. Stretch the skin at the injection site to create a firm and taut surface.
If someone else is giving you the injection, they can also use the outer area of the upper arms. For the upper arms, it is recommended to stretch the skin at the injection site to create a firm and taut surface.
Prepare the site
To prepare the area of skin where ENBREL® is to be injected, wipe the injection site with an alcohol swab. Do not touch this area again before giving the injection.
Injecting ENBREL® Using a Single-use Prefilled SureClick™ Autoinjector
1. Pull off the white needle cap.
⃠ Do not twist the white needle cap
⃠ Do not re-attach needle cap onto the prefilled autoinjector
✔ Do pull the white cap straight off.
2. Do not touch the purple button. Press prefilled autoinjector onto skin to unlock safety guard.
⃠ Do not press the purple button until the safety guard is fully retracted.
✔ Do keep enough downward pressure to fully retract the purple safety guard and to keep the purple button unlocked.
✔ Do hold the prefilled autoinjector at a right angle (90º) at the injection site.
3. Briefly press and release purple button.
✔ Do maintain pressure on the skin during the injection.
4. Count slowly to 15 seconds for injection to end.
⃠ Do not move the prefilled autoinjector during the injection.
✔ Do wait for the injection to finish before releasing pressure.
✔ You might hear a second click as the purple button pops back up.
After the Injection
Check window to confirm delivery of full dose.
There may be a little bleeding at the injection site. You can press a cotton ball or gauze over the injection site.
Do not rub the injection site. If needed, you may cover the injection site with a bandage.
Remember
If you have any problems, please call 1-888-4ENBREL (1-888-436-2735) for assistance.
Disposing of Supplies
The Sure |