; 62
(↓ 45 to
↓ 74) ↓ 56
(↓ 16 to
↓ 77)17
Maraviroc 100 mg bid 600 mg qd 12 ↓ 51
(↓ 37 to
↓ 62) ↓ 45
(↓ 38 to
↓ 51) ↓ 45
(↓ 28 to
↓ 57)
Clarithromycin 500 mg q12h × 7 days 400 mg qd × 7 days 11 ↓ 26
(↓ 15 to
↓ 35) ↓ 39
(↓ 30 to
↓ 46) ↓ 53
(↓ 42 to
↓ 63)
14-OH metabolite ↑ 49
(↑ 32 to
↑ 69) ↑ 34
(↑ 18 to
↑ 53) ↑ 26
(↑ 9 to
↑ 45)
Itraconazole 200 mg q12h × 28 days 600 mg qd × 14 days 18 ↓ 37
(↓ 20 to
↓ 51) ↓ 39
(↓ 21 to
↓ 53) ↓ 44
(↓ 27 to
↓ 58)
Hydroxy-itraconazole ↓ 35
(↓ 12 to
↓ 52) ↓ 37
(↓ 14 to
↓ 55) ↓ 43
(↓ 18 to
↓ 60)
Posaconazole 400 mg (oral suspension) bid × 10 and 20 days 400 mg qd × 10 and 20 days 11 ↓ 45
(↓ 34 to
↓ 53) ↓ 50
(↓ 40 to
↓ 57) NA
Rifabutin 300 mg qd × 14 days 600 mg qd × 14 days 9 ↓ 32
(↓ 15 to
↓ 46) ↓ 38
(↓ 28 to
↓ 47) ↓ 45
(↓ 31 to
↓ 56)
Atorvastatin 10 mg qd × 4 days 600 mg qd × 15 days 14 ↓ 14
(↓ 1 to
↓ 26) ↓ 43
(↓ 34 to
↓ 50) ↓ 69
(↓ 49 to
↓ 81)
Total active (including metabolites) ↓ 15
(↓ 2 to
↓ 26) ↓ 32
(↓ 21 to
↓ 41) ↓ 48
(↓ 23 to
↓ 64)
Pravastatin 40 mg qd × 4 days 600 mg qd × 15 days 13 ↓ 32
(↓ 59 to
↑ 12) ↓ 44
(↓ 26 to
↓ 57) ↓ 19
(↓ 0 to
↓ 35)
Simvastatin 40 mg qd × 4 days 600 mg qd × 15 days 14 ↓ 72
(↓ 63 to
↓ 79) ↓ 68
(↓ 62 to
↓ 73) ↓ 45
(↓ 20 to
↓ 62)
Total active (including metabolites) ↓ 68
(↓ 55 to
↓ 78) ↓ 60
(↓ 52 to
↓ 68) NAß
Carbamazepine 200 mg qd × 3 days, 200 mg bid × 3 days, then 400 mg qd × 29 days 600 mg qd × 14 days 12 ↓ 20
(↓ 15 to
↓ 24) ↓ 27
(↓ 20 to
↓ 33) ↓ 35
(↓ 24 to
↓ 44)
Epoxide metabolite ↔ ↔ ↓ 13
(↓ 30 to
↑ 7)
Diltiazem 240 mg × 21 days 600 mg qd × 14 days 13 ↓ 60
(↓ 50 to
↓ 68) ↓ 69
(↓ 55 to
↓ 79) ↓ 63
(↓ 44 to
↓ 75)
Desacetyl diltiazem ↓ 64
(↓ 57 to
↓ 69) ↓ 75
(↓ 59 to
↓ 84) ↓ 62
(↓ 44 to
↓ 75)
N-monodesmethyl diltiazem ↓ 28
(↓ 7 to
↓ 44) ↓ 37
(↓ 17 to
↓ 52) ↓ 37
(↓ 17 to
↓ 52)
Ethinyl estradiol/ Norgestimate 0.035 mg/0.25 mg × 14 days 600 mg qd × 14 days
Ethinyl estradiol 21 ↔ ↔ ↔
Norelgestromin 21 ↓ 46
(↓39 to
↓ 52) ↓ 64
(↓ 62 to
↓ 67) ↓ 82
(↓ 79 to
↓ 85)
Levonorgestrel 6 ↓ 80
(↓77 to
↓ 83) ↓ 83
(↓79 to
↓ 87) ↓ 86
(↓80 to
& |
