(↓ 25 to
↑ 3)
Carbamazepine 200 mg qd × 3 days, 200 mg bid × 3 days, then 400 mg qd × 15 days 600 mg qd × 35 days 14 ↓ 21
(↓ 15 to ↓ 26) ↓ 36
(↓ 32 to
↓ 40) ↓ 47
(↓ 41 to
↓ 53)
Diltiazem 240 mg × 14 days 600 mg qd × 28 days 12 ↑ 16
(↑ 6 to
↑ 26) ↑ 11
(↑ 5 to
↑ 18) ↑ 13
(↑ 1 to
↑ 26)
Sertraline 50 mg qd × 14 days 600 mg qd × 14 days 13 ↑ 11
(↑ 6 to
↑ 16) ↔ ↔
400 mg po q12h × 1 day then 200 mg po q12h × 8 days 400 mg qd × 9 days NA ↑ 38¶ ↑ 4410 NA
Voriconazole 300 mg po q12h days 2–7 300 mg qd × 7 days NA ↓ 14#
(↓ 7 to
↓ 21) ↔11 NA
400 mg po q12h days 2–7 300 mg qd × 7 days NA ↔11 ↑ 1711
(↑ 6 to
↑ 29) NA
6
7
8
9
10
11
Table 6 Drug Interactions: Changes in Pharmacokinetic Parameters for Coadministered Drug in the Presence of Efavirenz Mean % Change of Coadministered Drug Pharmacokinetic Parameters* (90% CI)
Coadministered Drug Dose of Coadministered Drug (mg) Efavirenz Dose (mg) N Cmax AUC Cmin
Atazanavir 400 mg qd with a light meal d 1–20 600 mg qd with a light meal d 7–20 27 ↓ 59
(↓ 49 to
↓ 67) ↓ 74
(↓ 68 to
↓ 78) ↓ 93
(↓ 90 to
↓ 95)
400 mg qd d 1–6, then 300 mg qd d 7–20 with ritonavir 100 mg qd and a light meal 600 mg qd 2 h after atazanavir and ritonavir d 7–20 13 ↑ 14†
(↓ 17 to
↑ 58) ↑ 3913
(↑ 2 to
↑ 88) ↑ 4813
(↑ 24 to
↑ 76)
300 mg qd/ritonavir 100 mg qd d 1–10 (pm), then 400 mg qd/ritonavir 100 mg qd d 11–24 (pm) (simultaneous with efavirenz) 600 mg qd with a light snack d 11–24 (pm) 14 ↑ 17
(↑ 8 to
↑ 27) ↔ ↓ 42
(↓ 31 to
↓ 51)
Indinavir 1000 mg q8h × 10 days 600 mg qd × 10 days 20
After morning dose ↔‡ ↓ 3314
(↓ 26 to
↓ 39) ↓ 3914
(↓ 24 to
↓ 51)
After afternoon dose ↔14 ↓ 3714
(↓ 26 to
↓ 46) ↓ 5214
(↓ 47 to
↓ 57)
After evening dose ↓ 2914
(↓ 11 to
↓ 43) ↓ 4614
(↓ 37 to
↓ 54) ↓ 5714
(↓ 50 to
↓ 63)
Lopinavir/
ritonavir 400/100 mg q12h × 9 days 600 mg qd × 9 days 11, 7§ ↔¶ ↓ 1916
(↓ 36 to
↑ 3) ↓ 3916
(↓ 3 to
↓ 62)
Nelfinavir 750 mg q8h × 7 days 600 mg qd × 7 days 10 ↑ 21
(↑ 10 to
↑ 33) ↑ 20
(↑ 8 to
↑ 34) ↔
Metabolite
AG-1402 ↓ 40
(↓ 30 to
↓ 48) ↓ 37
(↓ 25 to
↓ 48) ↓ 43
(↓ 21 to
↓ 59)
Ritonavir 500 mg q12h × 8 days 600 mg qd × 10 days 11
After AM dose ↑ 24
(↑ 12 to
↑ 38) ↑ 18
(↑ 6 to
↑ 33) ↑ 42
(↑ 9 to
↑ 86)#
After PM dose ↔ ↔ ↑ 24
(↑ 3 to
↑ 50)17
Saquinavir
SGCÞ 1200 mg q8h × 10 days 600 mg qd × 10 days 12 ↓ 50
(↓ 28 to
↓ 66) &darr
