pe each stopper with a sterile alcohol wipe and allow to dry.
•
Attach a syringe to a needle/needle-less transfer device . Due to the small stopper diameter; use an 18 – 22 gauge sterile needle for the 1.25 mL vial. A sterile needle or needle-less transfer device may be used for other vial sizes. Position the sharp tip of the needle/needle-less transfer device over the center of the vial stopper and insert it at a 90 degree angle. Inject air and then draw the full contents of each vial labeled “HY” into a single syringe, if possible.
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Attach the syringe containing the Recombinant Human Hyaluronidase to the subcutaneous needle set and prime up to the needle hub.
4.
Prepare Immune Globulin Infusion 10% (Human) of HYQVIA (Labeled as “IG”):
•
Wipe each stopper with a sterile alcohol wipe and allow to dry.
•
Transfer the vial(s) labeled “IG” using one of the following methods:
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Pool into an infusion bag, using a transfer device per manufacturer’s directions. Attach and prime the pump administrating tubing; or-
•
Directly spike the vial using a vented pump administration tubing and prime as directed.
If using a syringe driver, transfer into syringe(s), preferably using a vented spike.
5.
Prepare the infusion site(s):
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Potential sites for infusion include the middle to upper abdomen and thigh.
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Avoid: bony prominences, blood vessels, scars, or areas that are inflamed or infected.
•
If two sites are desired, a bifurcated needle set may be used on opposite sides of the body.
•
Rotate sites by choosing opposite sides of the body between successive infusions.
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Cleanse the infusion site(s) with a sterile alcohol wipe beginning at the center of each infusion site and moving outward in a circular motion. Allow the infusion site(s) to dry.
6.
Insert and secure the 24 gauge subcutaneous needle:
•
Pinch at least one inch of skin between two fingers. Insert the needle at a 90-degree angle into the subcutaneous tissue and secure the needle with sterile tape.
•
Check placement: gently pull back on the plunger of attached syringe and monitor for any blood return in the tubing.
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If blood is seen in the tubing, remove and discard the needle and repeat steps 3, 5 and 6 with a new subcutaneous needle and infusion site.
•
Secure the needle in place with a sterile protective dressing.
7.
Administer the Recombinant Human Hyaluronidase of HYQVIA:
Administer the entire Recombinant Human Hyaluronidase dose first. Start at a rate of 1 to 2 mL per minute per site and increase as tolerated. If more than one site is used, divide the contents equally between sites. At the end of infusion, disconnect the empty syringe and attach pump tubing/syringe containing the Immune Globulin Infusion 10% (Human) of HYQVIA to the same subcutaneous needle set.
8.
Administer the Immune Globulin Infusion 10% (Human) of HYQVIA:
Within approximately 10 minutes of completing the infusion of the Recombinant Human Hyaluronidase of HYQVIA, start the variable rate program of the infusion pump to initiate the infusion of the full therapeutic dose of Immune Globulin Infusion 10% (Human) of HYQVIA. At the end of infusion, flush infusion tubing up to the needle with normal saline or Dextrose 5% in water (D5W), if required.
9.
Remove subcutaneous needle(s) fr
