Who should not take JUVISYNC?

Do not take JUVISYNC if you:

•are allergic to any of the ingredients in JUVISYNC. See the end of this Medication Guide for a complete list of ingredients in JUVISYNC.

Symptoms of a serious allergic reaction to JUVISYNC may include:
•rash
•raised red patches on your skin (hives)
•swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing
•take certain medicines such as:
•anti-fungal medicines including:
•itraconazole
•ketoconazole
•posaconazole
•voriconazole
•HIV protease inhibitors, including:
•indinavir
•nelfinavir
•ritonavir
•saquinavir
•tipranavir
•atazanavir
•certain hepatitis C virus protease inhibitors, including:
•boceprevir
•telaprevir
•certain antibiotics, including:
•erythromycin
•clarithromycin
•telithromycin
•nefazodone
•a fibrate medicine for lowering cholesterol called gemfibrozil
•cyclosporine
•danazol

Ask your doctor if you are not sure whether your medicine is listed above.

•have active liver disease or repeated blood tests indicating possible liver problems.
•are pregnant or think you may be pregnant, or you are planning to become pregnant.
•are a woman of childbearing age, you should use an effective method of birth control to prevent pregnancy while using JUVISYNC.
•are breastfeeding or plan to breastfeed.
What should I tell my doctor before taking JUVISYNC?

Before you take JUVISYNC, tell your doctor if you:

•have or have had inflammation of your pancreas (pancreatitis).
•have kidney problems.
•drink substantial quantities of alcohol or ever had liver problems.
•have any other medical conditions.
•are taking drugs that prevent blood clots, such as warfarin.

Taking JUVISYNC with certain substances can increase the risk of muscle problems. It is especially important to tell your doctor if you take:
•fibric acid derivatives (such as fenofibrate)
•amiodarone or dronedarone (drugs used to treat an irregular heartbeat)
•the following medicines used to treat high blood pressure, chest pain with heart disease, or other heart problems:
•verapamil
•diltiazem
•amlodipine
•ranolazine
•grapefruit juice (which should be avoided while taking JUVISYNC)
•colchicine (a medicine used to treat gout)
•large doses of niacin or nicotinic acid

Tell your doctor if you are taking niacin or a niacin-containing product, as this may increase your risk of muscle problems, especially if you are Chinese.
Tell all of your doctors about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

How should I take JUVISYNC?

•Take one JUVISYNC tablet each day, in the evening, exactly as your doctor tells you.
•Do not break or cut JUVISYNC tablets before swallowing. If you cannot swallow