ercise alone. You should stay on a cholesterol-lowering diet while taking this medicine.
Sitagliptin is not for people with type 1 diabetes.
Sitagliptin is not for people with diabetic ketoacidosis (increased ketones in your blood or urine).
If you have had inflammation of your pancreas (pancreatitis) in the past, it is not known if you have a higher chance of getting pancreatitis while you take sitagliptin.
JUVISYNC has not been studied in people who have an increase of chylomicrons (Fredrickson types I and V).
JUVISYNC is not for people with certain kidney problems.
It is not known if JUVISYNC is safe and effective when used in children under 18 years of age.
For more information, see the sections called "What is type 2 diabetes?" and "What should I know about high cholesterol?".
Who should not take JUVISYNC?
Do not take JUVISYNC if you:
are allergic to any of the ingredients in JUVISYNC. See the end of this Medication Guide for a complete list of ingredients in JUVISYNC.
Symptoms of a serious allergic reaction to JUVISYNC may include:
rash
raised red patches on your skin (hives)
swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing
take certain medicines such as:
anti-fungal medicines including:
itraconazole
ketoconazole
posaconazole
HIV protease inhibitors, including:
indinavir
nelfinavir
ritonavir
saquinavir
tipranavir
atazanavir
certain hepatitis C virus protease inhibitors, including:
boceprevir
telaprevir
certain antibiotics, including:
erythromycin
clarithromycin
telithromycin
nefazodone
a fibrate medicine for lowering cholesterol called gemfibrozil
cyclosporine
danazol
Ask your doctor if you are not sure whether your medicine is listed above.
have active liver disease or repeated blood tests indicating possible liver problems.
are pregnant or think you may be pregnant, or you are planning to become pregnant.
are a woman of childbearing age, you should use an effective method of birth control to prevent pregnancy while using JUVISYNC.
are breastfeeding or plan to breastfeed.
What should I tell my doctor before taking JUVISYNC?
Before you take JUVISYNC, tell your doctor if you:
have or have had inflammation of your pancreas (pancreatitis).
have kidney problems.
drink substantial quantities of alcohol or ever had liver problems.
have any other medical conditions.
are taking drugs that prevent blood clots, such as warfarin.
Taking JUVISYNC with certain substances can increase the risk of muscle problems. It is especially important to tell your doctor if you take:
fibric acid derivatives (such as fenofibrate)
amiodarone (a drug used to treat an irregular heartbeat)
the following medicines used to treat high blood pressure, chest pain with heart disease, or other heart problems:
verapamil
diltiazem
amlodipine
ranolazine
large amounts of grapefruit juice (more than 1 quart daily)
colchicine (a medicine used to treat gout)
voriconazole (an anti-fungal medicine)
large doses of niacin or nicotinic acid
Tell your doctor if you are taking niacin or a niacin-containing product, as this may increase your risk of muscle problems, especially if you are Chinese.
Tell all of your doctors about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal su |
