Cardiac disorders
 
common:
 ischaemic coronary artery disorders, tachycardia
 
uncommon:
 ventricular arrhythmias and cardiac arrest, heart failures, cardiomyopathies, ventricular hypertrophy, supraventricular arrhythmias, palpitations
 
rare:
 pericardial effusion
 
very rare:
 Torsades de Pointes

 
Vascular disorders
 
very common:
 hypertension
 
common:
 haemorrhage, thrombembolic and ischaemic events, peripheral vascular disorders, vascular hypotensive disorders
 
uncommon:
 infarction, venous thrombosis deep limb, shock

 
Respiratory, thoracic and mediastinal disorders
 
common:
 dyspnoea, parenchymal lung disorders, pleural effusion, pharyngitis, cough, nasal congestion and inflammations
 
uncommon:
 respiratory failures, respiratory tract disorders, asthma
 
rare:
 acute respiratory distress syndrome

 
Gastrointestinal disorders
 
very common:
 diarrhoea, nausea
 
common:
 gastrointestinal inflammatory conditions, gastrointestinal ulceration and perforation, gastrointestinal haemorrhages, stomatitis and ulceration, ascites, vomiting, gastrointestinal and abdominal pains, dyspeptic signs and symptoms, constipation, flatulence, bloating and distension, loose stools, gastrointestinal signs and symptoms
 
uncommon:
 ileus paralytic, acute and chronic pancreatitis, gastrooesophageal reflux disease, impaired gastric emptying
 
rare:
 subileus, pancreatic pseudocyst

 
Hepatobiliary disorders
 
common:
 cholestasis and jaundice, hepatocellular damage and hepatitis, cholangitis
 
rare:
 hepatitic artery thrombosis, venoocclusive liver disease
 
very rare:
 hepatic failure, bile duct stenosis

 
Skin and subcutaneous tissue disorders
 
common:
 pruritus, rash, alopecias, acne, sweating increased
 
uncommon:
 dermatitis, photosensitivity
 
rare:
 toxic epidermal necrolysis (Lyell's syndrome)
 
very rare:
 Stevens Johnson syndrome

 
Musculoskeletal and connective tissue disorders
 
common:
 arthralgia, muscle spasms, pain in limb, back pain
 
uncommon:
 joint disorders

 
rare:
 mobility decreased

 
Renal and urinary disorders
 
very common:
 renal impairment
 
common:
 renal failure, renal failure acute, oliguria, renal tubular necrosis, nephropathy toxic, urinary abnormalities, bladder and urethral symptoms
 
uncommon:
 anuria, haemolytic uraemic syndrome
 
very rare:
 nephropathy, cystitis haemorrhagic

 
Reproductive system and breast disorders
 
uncommon:
 dysmenorrhoea and uter