This is not a complete list of medicines that can affect or be affected by SEROQUEL XR. Your doctor can tell you if it is safe to take SEROQUEL XR with your other medicines. Do not start or stop any medicines while taking SEROQUEL XR without talking to your healthcare provider first. Know the medicines you take. Keep a list of your medicines to show your healthcare provider and pharmacist when you get a new medicine.

How should I take SEROQUEL XR?

Take SEROQUEL XR exactly as your healthcare provider tells you to take it. Do not change the dose yourself.

Take SEROQUEL XR by mouth, with a light meal or without food.

SEROQUEL XR should be swallowed whole and not split, chewed or crushed.

If you feel you need to stop SEROQUEL XR, talk with your healthcare provider first.

If you suddenly stop taking SEROQUEL XR, you may experience side effects such as trouble sleeping or trouble staying asleep (insomnia), nausea, and vomiting.

If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed dose. Just take the next dose at your regular time. Do not take 2 doses at the same time unless your healthcare provider tells you to. If you are not sure about your dosing, call your healthcare provider.

If you take too much SEROQUEL XR, call your healthcare provider or poison control center at 1-800-222-1222 right away or go to the nearest hospital emergency room.

What should I avoid while taking SEROQUEL XR?

Do not drive, operate machinery, or do other dangerous activities until you know how SEROQUEL XR affects you. SEROQUEL XR may make you drowsy.

Avoid getting over-heated or dehydrated.

Do not over-exercise.

In hot weather, stay inside in a cool place if possible.

Stay out of the sun. Do not wear too much or heavy clothing.

Drink plenty of water.

Do not drink alcohol while taking SEROQUEL XR. It may make some side effects of SEROQUEL XR worse.

What are possible side effects of SEROQUEL XR?

Serious side effects have been reported with SEROQUEL XR including:

Also see “What is the most important information I should know about SEROQUEL XR?” at the beginning of this Medication Guide

Neuroleptic malignant syndrome (NMS): Tell your healthcare provider right away if you have some or all of the following symptoms: high fever, stiff muscles, confusion, sweating, changes in pulse, heart rate, and blood pressure. These may be symptoms of a rare and serious condition that can lead to death. Stop SEROQUEL XR and call your healthcare provider right away.

High blood sugar (hyperglycemia): Increases in blood sugar can happen in some people who take SEROQUEL XR. Extremely high blood sugar can lead to coma or death. If you have diabetes or risk factors for diabetes (such as being overweight or a family history of diabetes) your healthcare provider should check your blood sugar before you start SEROQUEL XR and during therapy.

Call your healthcare provider if you have any of these symptoms of high blood sugar while taking SEROQUEL XR:

feel very thirsty

need to urinate more than usual

feel very hungry

feel weak or tired

feel sick to your stomach

feel confused, or your breath smells fruity.

High cholesterol and triglyceride levels in the blood (fat in the blood) Increases in total cholesterol, triglycerides and LDL (bad) cholesterol and decreases in HDL (good) cholesterol have been reported in clinical trials with SEROQUEL XR. You may not have any sympto