See the section “What is the most important information I need to know about receiving Neulasta with the On-body Injector for Neulasta?”

Neulasta is given as an injection under the skin (subcutaneous). Your healthcare provider will use a prefilled syringe with Neulasta to fill the On-body Injector prior to applying it. The prefilled syringe with Neulasta and the On-body Injector are provided to your healthcare provider as part of Neulasta OnproTM kit. The On-body Injector for Neulasta will be applied to the stomach area (abdomen) or back of your arm by your healthcare provider.  If the On-body Injector for Neulasta was placed on the back of your arm, a caregiver must be available to monitor the On-body Injector for Neulasta.

Your healthcare provider should place the On-body Injector for Neulasta on an area of your skin that does not have swelling, redness, cuts, wounds, or abrasions. Tell your healthcare provider about any skin reactions that happen in the On-body Injector for Neulasta application area after it has been applied.

The On-body Injector for Neulasta is programmed to deliver your dose about 27 hours after your healthcare provider places the On-body Injector for Neulasta on your skin.

The dose of Neulasta will be delivered over about 45 minutes. During dose delivery and for 1 hour after delivery, it is best to stay in a place where you or a caregiver can monitor the On-body Injector for Neulasta to make sure you receive your full dose of Neulasta and watch for symptoms of an allergic reaction.

Keep the On-body Injector for Neulasta dry for about the last 3 hours before the dose delivery is expected to start. This will help you to better detect possible leaking from the On-body Injector for Neulasta.

Only expose the On-body Injector for Neulasta to temperatures between 41°F to 104°F (5°C to 40°C).
What should I avoid while the On-body Injector for Neulasta is in place?

While the On-body Injector for Neulasta is in place you should avoid:

traveling, driving or operating heavy machinery during hour 26 through hour 29 after the On-body Injector for Neulasta is applied.

sleeping on the On-body Injector for Neulasta or applying pressure on the On-body Injector for Neulasta. The On-body Injector for Neulasta may not work properly.

bumping the On-body Injector for Neulasta or knocking it off your body.

getting body lotion, creams, oils, and skin cleansing products near the On-body Injector for Neulasta. These products may loosen the adhesive that holds the On-body Injector for Neulasta onto your body.

using hot tubs, whirlpools, or saunas, and direct sunlight. These may affect Neulasta.

peeling off or disturbing the On-body Injector for Neulasta adhesive before you receive your full dose of Neulasta.
What are possible side effects of Neulasta?

Neulasta can cause serious side effects, including:

Spleen rupture. Your spleen may become enlarged or may rupture during treatment with Neulasta. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in your left upper stomach area or left shoulder area.  This pain could mean your spleen is enlarged or ruptured.
A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your hea