Manufactured by:
Patheon, Inc.
Mississauga, Ontario, Canada L5N 7K9

U.S. Patent Nos. RE 38,506 E; 6,087,367

Copyright © 2006, 2008, 2009, 2011, 2013 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
All rights reserved.

Revised: 04/2013

USPI-C-0683-1304R006
Patient Information
ZOLINZA® (zo LINZ ah)
(vorinostat)
Capsules

Read the patient information that comes with ZOLINZA before you start taking it and each time you get a refill. There may be new information. This leaflet is a summary of the information for patients. Your doctor or pharmacist can give you additional information. This leaflet does not take the place of talking with your doctor about your medical condition or your treatment.

What is ZOLINZA?

ZOLINZA is a prescription medicine used to treat a type of cancer called cutaneous T-cell lymphoma (CTCL) in patients when the CTCL gets worse, does not go away, or comes back after treatment with other medicines.

ZOLINZA has not been studied in children under the age of 18.

What should I tell my doctor before taking ZOLINZA?

Tell your doctor about all of your medical conditions, including if you:

•Have any allergies
•Have had a blood clot in your lung (pulmonary embolus)
•Have had a blood clot in a vein (a blood vessel) anywhere in your body (deep vein thrombosis)
•Have nausea, vomiting, or diarrhea
•Have liver disease
•Have high blood sugar or diabetes
•Are pregnant or plan to become pregnant. ZOLINZA may harm your unborn baby. ZOLINZA has not been studied in pregnant women. If you use ZOLINZA during pregnancy, tell your doctor immediately.
•Are breastfeeding or plan to breastfeed. It is not known if ZOLINZA will pass into your breast milk. Talk to your doctor about the best way to feed your baby while you are taking ZOLINZA.
Tell your doctor about all of the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Some medicines may affect how ZOLINZA works, or ZOLINZA may affect how your other medicines work. Especially tell your doctor if you take:

•Valproic acid: a medicine used to treat seizures. Your doctor will decide if you should continue to take valproic acid and may want to test your blood more frequently.
•COUMADIN®: (warfarin) or any other blood thinner. Ask your doctor if you are not sure if you are taking a blood thinner. Your doctor may want to test your blood more frequently.
Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

How should I take ZOLINZA?

•Take ZOLINZA exactly as your doctor tells you to.
•Your doctor will tell you how many ZOLINZA capsules to take and when to take them.
•Swallow each capsule whole. Do not chew or break open the capsule. If you can't swallow ZOLINZA capsules whole, tell your doctor. You may need a different medicine.
•Take ZOLINZA with food.
•If ZOLINZA capsules are accidentally opened or crushed, do not touch the capsules or the powder contents of the capsules. If the powder from an open or crushed capsule gets on your skin or in your eyes, wash the contacted area well with plenty of plain water. Call your doctor.
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