extreme somnolence progressing to stupor, loss of consciousness, or coma, skeletal muscle
flaccidity, cold and clammy skin and other symptoms common with narcotic overdosage.
Convulsions, cardiovascular collapse, and death may occur. A single case of acute rhabdomyolysis
associated with an overdose of dihydrocodeine has been reported.
Recommended Treatment: Immediate treatment of an overdosage of CENTUSSIN DHC Liquid
includes support of cardiorespiratory function and measures to reduce drug absorption. Vomiting
should be induced with syrup of ipecac, if the patient is alert and has adequate laryngeal reflexes.
Oral activated charcoal should follow. The first dose should be accompanied by an appropriate
cathartic. Gastric lavage may be necessary. Hypotension is usually hypovolemic and should be
treated with fluids. Endotracheal intubation and artificial respiration may be necessary. The pure
opioid antagonist naloxone or nalmefene is a specific antidote against respiratory depression that
results from opioid overdose. Opioid antagonists should not be given in the absence of clinically
significant respiratory or circulatory depression secondary to opioid overdose. They should be
administered cautiously to persons who are known, or suspected to be, physically dependent on
any opioid agonist including dihydrocodeine. In such cases, an abrupt or complete reversal of
opioid effects may precipitate an acute abstinence syndrome. The prescribing information for the
specific opioid antagonist should be consulted for details of their proper use.
DOSAGE AND ADMINISTRATION*
Adults and Children 12 years of age or older:
1 teaspoonful every 4 to 6 hours. Not to exceed 6 teaspoonfuls in a 24 hour period.
Children 6 to 12 years of age: 1/2 teaspoonful every 4 to 6 hours. Not to exceed
3 teaspoonfuls in a 24 hour period.
Not recommended for children under 6 years of age.
*In mild cases or in particularly sensitive patients, less frequent or reduced doses may be
appropriate and adequate.
HOW SUPPLIED
A clear colored liquid with a grape flavor supplied in 16 oz. bottles (NDC 23359-018-16).
KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.
IN CASE OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE
OR CONTACT A POISON CONTROL CENTER IMMEDIATELY.
Tamper evident by foil seal under cap. Do not use if foil seal is broken or missing.
This bottle is not to be dispensed to consumer.
Storage:
Store at 15o-30oC (59o-86oF). [See USP Controlled Room Temperature.]
Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.
Rx Only
Manufactured for:
Centurion Labs, LLC
Birmingham, AL 35236
Rev. 11/09
PRODUCT PACKAGING:
The packaging below represents the labeling currently used:
NDC 23359-018-16
CENTUSSIN DHC LIQUID
ANTITUSSIVE
ANTIHISTAMINE
DECONGESTANT
EACH TEASPOONFUL (5 mL) CONTAINS:
Dihydrocodeine Bitartrate*........ 3 mg
*(WARNING-May be habit forming)
Brompheniramine Maleate....... 4 mg
Phenylephrine HCl................ 7.5 mg
Grape Flavor
CV
16 fl oz. (473 mL)
Rx Only
Side Panel:
DOSAGE AND ADMINISTRATION*:Adults and Children 12 years of age and older:
1 teaspoonful every 4 to 6 hours. Not to exceed 6 teaspoonfuls in a 24 hour period.
Children 6 to 12 years of age: 1/2 teaspoonf
