Signs and Symptoms: Symptoms of overdosage include pinpoint pupils, respiratory depression,
extreme somnolence progressing to stupor, loss of consciousness, or coma, skeletal muscle
flaccidity, cold and clammy skin and other symptoms common with narcotic overdosage.
Convulsions, cardiovascular collapse, and death may occur. A single case of acute
rhabdomyolysis associated with an overdose of dihydrocodeine has been reported.

Recommended Treatment: Immediate treatment of an overdosage of POLY HIST DHC
Liquid includes support of cardiorespiratory function and measures to reduce drug absorption.
Vomiting should be induced with syrup of ipecac, if the patient is alert and has adequate laryngeal
reflexes. Oral activated charcoal should follow. The first dose should be accompanied by an
appropriate cathartic. Gastric lavage may be necessary. Hypotension is usually hypovolemic and
should be treated with fluids. Endotracheal intubation and artificial respiration may be necessary.
The pure opioid antagonist naloxone or nalmefene is a specific antidote against respiratory depression
that results from opioid overdose. Opioid antagonists should not be given in the absence of clinically
significant respiratory or circulatory depression secondary to opioid overdose. They should be
administered cautiously to persons who are known, or suspected to be, physically dependent on any
opioid agonist including dihydrocodeine. In such cases, an abrupt or complete reversal of opioid
effects may precipitate an acute abstinence syndrome. The prescribing information for the specific
opioid antagonist should be consulted for details of their proper use.

DOSAGE AND ADMINISTRATION*
Adults and Children 12 years of age and older:
1 teaspoonful every 4 to 6 hours. Not to exceed 6 teaspoonfuls in a 24 hour period.
Children 6 to 12 years of age:
1/2 teaspoonful every 4 to 6 hours. Not to exceed 3 teaspoonfuls in a 24 hour period.
Not recommended for children under 6 years of age.

*In mild cases or in particularly sensitive patients, less frequent or reduced doses
may be appropriate and adequate.

HOW SUPPLIED
POLY HIST DHC is supplied as an alcohol free, gluten free, sugar free, fruit gum flavor,
clear colored liquid supplied in 16 oz. bottles (NDC 50991-521-16) and 15 mL professional
sample (NDC 50991-521-15).

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.
IN CASE OF ACCIDENTAL OVERDOSE, SEEK PROFESSIONAL ASSISTANCE
OR CONTACT A POISON CONTROL CENTER IMMEDIATELY.

Tamper evident by foil seal under cap. Do not use if foil seal is broken or missing.

Storage:
Store at 20o-25oC (68o-77oF); excursions permitted to 15o-30oC (59o-86oF).
[See USP Controlled Room Temperature.] Protect from freezing.

Dispense in a tight, light-resistant container as defined in the USP/NF with a child-resistant closure.

This bottle not to be dispensed to consumer.

Rx only

Manufactured by:
Great Southern Laboratories
Houston, TX 77099

Distributed for:
Poly Pharmaceuticals
Mobile, AL 36619

Rev. 09/09

PRODUCT PACKAGING:
The packaging below represents the labeling currently used:

Principal Display Panel and Side Panel for 473mL Label:

NDC 50991-521-16

POLY HIST DHC

Antitussive / Decongestant / Antihistamine

Each 5 mL (1 teaspoonful) contains:
Dihydrocodeine Bit