taxel.
Table 1: Adverse Reactions by Frequency
System organ class
Very Common
Common
Uncommon
Rare
Very Rare
Frequency Not Known
Infections and infestations
Sepsis, Abscessb,d, Cellulitis, Infection, Urinary tract infection
Necrotising fasciitis a
Blood and lymphatic system disorders
Febrile neutropenia, Leucopenia, Neutropeniab, Thrombo-cytopenia
Anaemia, Lymphopenia
Immune system disorders
Hypersensitivity, infusion reactionsa,b,d
Metabolism and nutrition disorders
Anorexia
Dehydration
Nervous system disorders
Peripheral sensory neuropathyb, Dysarthria, Headache, Dysguesia
Cerebrovascular accident, Syncope, Somnolence
Posterior reversible encephalopathy syndrome a,b,d
Hypertensive encephalo-pathya
Eye disorders
Eye disorder, Lacrimation increased
Cardiac disorders
Congestive heart failureb,d, Supraventricular tachycardia
Vascular disorders
Hypertensionb,d, Thrombo-embolism (venous)b,d
Thromboembolism (arterial)b,d, Haemorrhageb,d, Deep vein thrombosis
Renal thrombotic microangiopathya,b
Respiratory, thoracic and mediastinal disorders
Dyspnoea, Rhinitis
Pulmonary haemorrhage/ Haemoptysisb,d, Pulmonary embolism, Epistaxis, Hypoxia, Dysphoniaa
Pulmonary hypertensiona, Nasal septum perforationa
Gastrointestinal disorders
Rectal haemorrhage, Stomatitis, Constipation, Diarrhoea, Nausea, Vomiting, Abdominal pain
Gastrointestinal perforationb,d, Intestinal perforation, Ileus, Intestinal obstruction, Recto-vaginal fistulaed,e, Gastrointestinal Disorder, Proctalgia
Gastrointestinal ulcera
Hepatobiliary disorders
Gallbladder perforationa,b
Skin and subcutaneous tissue disorders
Wound healing complicationsb,d, Exfoliative dermatitis, Dry skin, Skin discoloration
Palmar-plantar erythrodysaesthesia syndrome
Musculoskeletal and connective tissue disorders
Arthralgia
Fistulab,d, Myalgia, Muscular weakness, Back pain
Osteonecrosis of the jawa,b
Non-mandibular osteonecrosisa,f
Renal and urinary disorders
Proteinuriab,d
Reproductive system and breast disorders
Ovarian failureb,c,d
Pelvic Pain
Congenital, familial, a
