Table 3. Frequency of adverse reactions with hydrochlorothiazide

Hydrochlorothiazide has been extensively prescribed for many years, frequently in higher doses than those administered with Co-Diovan. The following adverse reactions have been reported in patients treated with monotherapy of thiazide diuretics, including hydrochlorothiazide:

Blood and lymphatic system disorders
 
Rare
 Thrombocytopenia sometimes with purpura
 
Very rare
 Agranulocytosis, leucopenia, haemolytic anaemia, bone marrow failure
 
Not known
 Aplastic anemia
 
Immune system disorders
 
Very rare
 Hypersensitivity reactions
 
Metabolism and nutrition disorders
 
Very common
 Hypokalaemia, blood lipids increased (mainly at higher doses)
 
Common
 Hyponatraemia, hypomagnesaemia, hyperuricaemia
 
Rare
 Hypercalcaemia, hyperglycaemia, glycosuria and worsening of diabetic metabolic state
 
Very rare
 Hypochloraemic alkalosis
 
Psychiatric disorders
 
Rare
 Depression, sleep disturbances
 
Nervous system disorders
 
Rare
 Headache, dizziness, paraesthesia
 
Eye disorders
  
Rare
 Visual impairment
 
Not known
 Acute angle-closure glaucoma
 
Cardiac disorders
 
Rare
 Cardiac arrhythmias
 
Vascular disorders
 
Common
 Postural hypotension
 
Respiratory, thoracic and mediastinal disorders
 
Very rare
 Respiratory distress including pneumonitis and pulmonary oedema
 
Gastrointestinal disorders
 
Common
 Loss of appetite, mild nausea and vomiting
 
Rare
 Constipation, gastrointestinal discomfort, diarrhoea
 
Very rare
 Pancreatitis
 
Hepatobiliary disorders
 
Rare
 Intrahepatic cholestasis or jaundice
 
Renal and urinary disorders
  
Not known
 Renal dysfunction, acute renal failure
 
Skin and subcutaneous tissue disorders
 
Common
 Urticaria and other forms of rash
 
Rare
 Photosensitisation
 
Very rare
 Necrotising vasculitis and toxic epidermal necrolysis, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus
 
Not known
 Erythema multiforme
 
General disorders and admi