For more information, go to www.TOBIPodhaler.com or call 1-877-999-TOBI (8624).

What are the ingredients in TOBI Podhaler?

Active ingredient: tobramycin

Inactive ingredients: 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), calcium chloride, and sulfuric acid (for pH adjustment)

What is Pseudomonas aeruginosa?

It is a very common bacterium that infects the lungs of nearly everyone with cystic fibrosis at some time during their lives. Some people do not get this infection until later in their lives, while others get it very young. It is one of the most damaging bacteria for people with cystic fibrosis. If the infection is not properly managed, it will continue to damage your lungs causing further problems to your breathing.

T2013-21
March 2013
Instructions for Use

TOBI Podhaler

Follow the instructions below for using your TOBI Podhaler. You will breathe in (inhale) the medicine in the TOBI Podhaler capsules using the Podhaler device. If you have any questions, ask your healthcare provider or pharmacist.
Each TOBI Podhaler package contains (See Figure A):

4 weekly packs (28-day supply), each containing:
56 capsules (7 blister cards of 8 capsules). Each blister card contains 8 TOBI Podhaler capsules (4 capsules for inhalation in the morning and 4 capsules for inhalation in the evening).
1 Podhaler device and its storage case
1 reserve Podhaler device (to be used if needed) and its storage case
Please note the following:

Do not swallow TOBI Podhaler capsules. The powder in the capsule is for you to inhale using the Podhaler device.
Only use the Podhaler device contained in this pack. Do not use TOBI Podhaler capsules with any other device, and do not use the Podhaler device to take any other medicine.
When you start a new weekly (7 day) pack of capsules, use the new Podhaler device that is supplied in the pack and discard the used device and its case. Each Podhaler device is only used for one week (7 days).
Always keep the TOBI Podhaler capsules in the blister card. Only remove 1 capsule at a time just before you are going to use it.
Doses should be inhaled as close to 12 hours apart as possible and not less than 6 hours apart.
Once in a while, very small pieces of the capsules can get into your mouth and you may be able to feel these pieces on your tongue. These small pieces will not hurt you if you swallow or inhale them.
The reserve Podhaler device provided in the package may be used if the Podhaler device:
is wet, dirty, or broken
has been dropped
does not seem to be piercing the capsule properly (see Step 17)
Getting ready:
Wash and dry your hands completely (See Figure B).
Figure B

Preparing your TOBI Podhaler dose

Step 1: Just before use, hold the base of the Podhaler device and unscrew the lid in a counter-clockwise direction (See Figure C). Set the lid aside.
Figure C
Step 2: Stand the Podhaler device upright in the base of the case (See Figure D).
Figure D
Step 3: Hold the body of the Podhaler device and unscrew the mouthpiece in a counter-clockwise direction (See Figure E). Set the mouthpiece aside on a clean, dry surface.
Figure E
Step 4: Take 1 blister card and tear the pre-cut lines along the length (See Figure F) then tear at the pre-cut lines along the width (See Figure G).
Step 5: Peel (by rolling back) the foil that covers 1 TOBI Podhaler capsule on the blis