ty (eg, hepatomegaly, steatosis) occurs. Not for treating chronic hepatitis B; test for HBV before starting therapy and closely monitor patients co-infected with HBV and HIV during and for several months after stopping treatment (discontinuing therapy may exacerbate HBV infection). Monitor creatinine clearance, urine glucose, urine protein, serum phosphorus (for patients at risk for renal impairment). History of pathologic fracture or risk factors of osteoporosis or bone loss: consider monitoring bone mineral density (BMD). Pregnancy (Cat. B). Nursing mothers: not recommended.
Interaction(s)
See Contraindications. Avoid with concurrent or recent use of nephrotoxic agents. Do not administer with other antiretroviral agents. May be potentiated by CYP3A inhibitors, antagonized by CYP3A inducers. May potentiate drugs metabolized by CYP3A or CYP2D6, or are substrates of P-gp, BCRP, OATP1B1 or OATP1B3. May antagonize CYP2C9 substrates. Separate antacids by at least 2 hours. May potentiate antiarrhythmics, digoxin, clarithromycin (reduce dose by 50% if CrCl 50–60mL/min), telithromycin, carbamazepine, clonazepam, ethosuximide, SSRIs, TCAs, trazodone, ketoconazole (max 200mg/day), itraconazole (max 200mg/day), voriconazole, beta-blockers, calcium channel blockers, fluticasone (use alternative corticosteroid), atorvastatin, immunosuppressants, (monitor), neuroleptics, sedatives/hypnotics, PDE5 inhibitors (see literature for dose adjustments). Antagonized by carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifapentine, systemic dexamethasone. Concomitant colchicine (see literature); do not coadminister to patients with renal or hepatic impairment. Discontinue use of bosentan at least 36 hours prior to initiation of Stribild; after at least 10 days following initiation, resume bosentan. Concomitant salmeterol: not recommended; increased risk of cardiovascular events. Use alternative non-hormonal methods of contraception. Monitor INR.
Adverse Reaction(s)
Nausea, diarrhea; decreased BMD, fat redistribution, immune reconstitution syndrome.
How Supplied:
Tabs—30
LAST UPDATED:
12/1/2012
