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KUVAN (sapropterin dihydrochloride) tablets(十五)
2015-08-13 10:31:57 来源: 作者: 【 】 浏览:7567次 评论:0
nd when to take it.
Your doctor may change your dose of Kuvan depending on how you respond to treatment.
Take Kuvan 1 time each day with a meal. It is best to take Kuvan at the same time each day.
Kuvan comes as a tablet and powder for oral solution.
You can swallow Kuvan tablets whole or dissolve the tablets in water or apple juice. You may also crush the tablets and mix in a small amount of soft food, such as apple sauce or pudding before taking.
Be sure that you know what dose of Kuvan powder your doctor prescribed and whether you should use Kuvan 100 mg packets, Kuvan 500 mg packets, or both types of packets to prepare your dose.
Open Kuvan powder packets only when you are ready to use them.
Kuvan powder for oral solution should be dissolved in water or apple juice. You may also mix the powder for oral solution in a small amount of soft food, such as apple sauce or pudding before taking.
See the detailed “Instructions for Use” that comes with Kuvan for information about the correct way to dissolve and take a dose of Kuvan tablets or Kuvan powder for oral solution.
It is not possible to know if Kuvan will work for you until you start taking Kuvan. Your doctor will check your blood Phe levels when you start taking Kuvan to see if the medicine is working.
During treatment with Kuvan:
Any change you make to your diet may affect your blood Phe level. Follow your doctor’s instructions carefully and do not make any changes to your dietary Phe intake without first talking with your doctor. Even if you take Kuvan, if your Phe blood levels are not well controlled, you can develop severe neurologic problems. 
Your doctor should continue to monitor your blood Phe levels often during your treatment with Kuvan, to make sure that your blood Phe levels are not too high or too low.
If you have a fever, or if you are sick, your blood Phe level may go up. Tell your doctor as soon as possible so they can change your dose of Kuvan to help keep your blood Phe levels in the desired range.
If you forget to take your dose of Kuvan, take it as soon as you remember that day. Do not take 2 doses in a day.
If you take too much Kuvan, call your doctor for advice.
What are the possible side effects of Kuvan?

Kuvan can cause serious side effects, including:

Severe allergic reactions. Stop taking Kuvan and get medical help right away if you develop any of these symptoms of a severe allergic reaction:
wheezing or trouble breathing
coughing
rash
feeling lightheaded or you faint
flushing
nausea
Inflammation of the lining of the stomach (gastritis). Gastritis can happen with Kuvan and may be severe. Call your doctor right away if you have any of these signs or symptoms:
severe upper stomach-area (abdominal) discomfort or pain, nausea and vomiting
blood in your vomit or stool
black, tarry stools
Phe levels that are too low.  Some children under the age of 7 who take high doses of Kuvan each day may experience low Phe levels. 
Too much or constant activity (hyperactivity) can happen with Kuvan. Tell your doctor if you have any signs of hyperactivity, including:
fidgeting or moving around too much
talking too much
The most common side effects of Kuvan are:

headache
runny nose and nasal congestion
sore throat
diarrhea
vomiting
cough
Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Kuvan. For more information, ask your doctor or pharmacist. Call your d

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