Common

Febrile Neutropenia, Anaemia

Uncommon

Hypercoagulation, Coagulopathy
 
Immune System Disorders
 Uncommon

Hypersensitivity^
 
 
Endocrine Disorders
 Common

Hypothyroidism
 
Metabolism and Nutrition Disorders
 Very Common

Hypokalaemia, Decreased appetite

Common

Hypomagnesaemia, Hypocalcaemia, Dehydration
 Common

Hypokalaemia, Hypocalcaemia, Hypophosphataemia
 
Psychiatric Disorder
 Uncommon

Loss of libido
 Common

Depression
 
Nervous System disorders
 Very Common

Peripheral neuropathies (excluding motor neuropathy), Dizziness, Tremor, Dysgeusia, Headache

Common

Ataxia, Balance impaired
 Common

Cerebrovascular Accident, Dizziness, Syncope
Uncommon

Intracranial haemorrhage^, Transient ischaemic attack, Cerebral ischaemia
 
Eye Disorders
 Very Common

Blurred vision

Common

Reduced visual acuity, Cataract
 Common

Cataract

Uncommon

Blindness
 
Ear and Labyrinth Disorders
 Common

Deafness (Including Hypoacusis), Tinnitus
 
Cardiac Disorders
 Common

Atrial Fibrillation, Bradycardia

Uncommon

Arrhythmia, QT prolongation, Atrial flutter, Ventricular extrasystoles
 Common

Myocardial infarction^, Atrial Fibrillation, Congestive Cardiac, Failure, Tachycardia
 
Vascular Disorders
 Very Common

Venous Thromboembolic Events, predominantly Deep Vein Thrombosis and Pulmonary Embolism^

Common

Hypotension, Hypertension, Ecchymosis^
 Very Common

Venous Thromboembolic Events, predominantly Deep Vein Thrombosis and Pulmonary Embolism^

Uncommon

Ischemia, Peripheral ischemia, Intracranial venous sinus thrombosis
 
Respiratory, Thoracic and Mediastinal Disorders
 Very common

Dyspnoea, Nasopharyngitis, Pharyngitis, Bronchitis, Epistaxis^
 Common

Respiratory Distress
 
Gastrointestinal Disorders
 Very Common

Constipation, Diarrhoea, Nausea, Vomiting

Common

Gastrointestinal Haemorrhage (including rectal haemorrhage, haemorrhoidal haemorrhage, peptic ulcer haemorrhage and gingival bleeding)^, Abdominal Pain, Dry Mouth, Stomatitis, Dysphagia

Uncommon

Colitis, Caecitis
 Common

Diarrhoea, Constipation, Nausea

 
Hepatobiliary Disorders
 Common

Abnormal Liver Function Tests
 Common

Abnormal Liver Function Tests
 
Skin and Subcutaneous tissue Disorders
 Very Common

Rashes

Common

Urticaria, Hyperhidrosis, Dry Skin, Pruritus, Skin Hyperpigmentation, Eczema

Uncommon

Skin discolouration, Photosensitivity reaction
 Common

Rashes
 
Musculoskeletal and connective tissue disorders
 Very Common

Muscle Spasms, Bone Pain, Musculoskeletal and connective tissue pain and discomfort

Common

Joint swelling
 Common

Muscle Weakness, Bone Pain

Uncommon

Joint swelling
 
Renal and Urinary Disorders
 Common

Haematuria^, Uri