Your doctor should do blood tests to check your liver before you start JUXTAPID, if your dose is increased, and while you take JUXTAPID. If your tests show some liver problems, your doctor may adjust your dose of JUXTAPID or stop it altogether.
Tell your doctor if you have had liver problems, including liver problems while taking other medicines.
JUXTAPID may cause nausea, vomiting and stomach pain, especially if you do not eat a low-fat diet. These side effects can also be symptoms of liver problems. Tell your doctor right away if you have any of these symptoms of liver problems while taking JUXTAPID:
nausea, vomiting or stomach pain that gets worse, does not go away, or changes
fever
yellowing of your eyes or skin
you are more tired than usual
flu-like symptoms
Drinking alcohol may increase your chance of having liver problems or make your liver problems worse. You should not have more than 1 alcoholic drink each day while taking JUXTAPID.
2. Harm to your unborn baby. JUXTAPID may cause harm to your unborn baby.

If you are pregnant, think you may be pregnant, or are planning to become pregnant, do not take JUXTAPID.
If you are a female who can get pregnant, you should have a pregnancy test before you start taking JUXTAPID. Your pregnancy test must be negative for you to get JUXTAPID.
Do not have sex while taking JUXTAPID unless you are using effective birth control.
Talk with your doctor or nurse to find the best method of birth control for you.
Birth control pills may not work as well if you have diarrhea or vomiting.
If you start taking birth control pills while you are taking JUXTAPID, tell your doctor. Your doctor might need to change your dose of JUXTAPID.
If you become pregnant while taking JUXTAPID, stop taking JUXTAPID and call your doctor right away.
Pregnancy Exposure Registry: There is a pregnancy exposure registry that monitors outcomes in women exposed to JUXTAPID during pregnancy. If you become pregnant while taking JUXTAPID, call 1-877-902-4099 or visit www.JUXTAPID.com for more information about the JUXTAPID pregnancy exposure registry.
What is JUXTAPID?

JUXTAPID is a prescription medicine used along with diet and other lipid-lowering treatments, including low-density lipoprotein (LDL) apheresis where available, in people with homozygous familial hypercholesterolemia (HoFH) to reduce:

LDL (“bad”) cholesterol
total cholesterol
a protein that carries “bad” cholesterol in the blood (apolipoprotein B)
non-high-density lipoprotein cholesterol (non-HDL-C)
It is not known if JUXTAPID can decrease problems from high cholesterol, such as heart attack, stroke, death or other health problems.

It is not known if JUXTAPID is safe in people with high cholesterol but who do not have HoFH.

JUXTAPID should not be taken with certain medicines or food. You should not drink grapefruit juice. Ask your doctor or pharmacist to make sure you can take JUXTAPID with your other medicines, and tell your doctor about any new medicines you might take even for only a short time.

It is not known if JUXTAPID is safe and effective in people with kidney problems including people with end-stage kidney disease who are not on dialysis.

It is not known if JUXTAPID is safe and effective when used in children under the age of 18.

Who should not take JUXTAPID?

Do not take JUXTAPID if you:

are pregnant, think you may be pregnant, or are plannin