ssessed to be possibly drug–related.
Gemzar plus Cisplatin†
Cisplatin‡
All Grades
Grade
3
Grade
4
All Grades
Grade
3
Grade
4
Laboratory
Hematologic
Anemia
89
22
3
67
6
1
RBC Transfusion¶
39
13
Leukopenia
82
35
11
25
2
1
Neutropenia
79
22
35
20
3
1
Thrombocytopenia
85
25
25
13
3
1
Platelet Transfusions¶
21
<1
Lymphocytes
75
25
18
51
12
5
Hepatic
Transaminase
22
2
1
10
1
0
Alkaline Phosphatase
19
1
0
13
0
0
Renal
Proteinuria
23
0
0
18
0
0
Hematuria
15
0
0
13
0
0
Creatinine
38
4
<1
31
2
<1
Other Laboratory
Hyperglycemia
30
4
0
23
3
0
Hypomagnesemia
30
4
3
17
2
0
Hypocalcemia
18
2
0
7
0
<1
Non–laboratory#
Nausea
93
25
2
87
20
<1
Vomiting
78
11
12
71
10
9
Alopecia
53
1
0
33
0
0
Neuro Motor
35
12
0
15
3
0
Constipation
28
3
0
21
0
0
Neuro Hearing
25
6
0
21
6
0
Diarrhea
24
2
2
13
0
0
Neuro Sensory
23
1
0
18
1
0
Infection
18
3
2
12
1
0
Fever
16
0
0
5
0
0
Neuro Cortical
16
3
1
9
1
0
Neuro Mood
16
1
0
10
1
0
Local
15
0
0
6
0
0
Neuro Headache
14
0
0
7
0
0
Stomatitis
14
1
0
5
0
0
Hemorrhage
14
1
0
4
0
0
Dyspnea
12
4
3
11
3
2
Hypotension
12
1
0
7
1
0
Rash
11
0
0
3
0
0
Grade based on Common Toxicity Criteria (CTC). Table includes data for adverse events with incidence ≥10% in either arm.
N=217–253; all Gemzar plus cisplatin patients with l |
