athing difficulties
chest pain
increase in heart rate (pulse)
shortness of breath
These are serious side effects. You may need urgent medical attention. Serious side effects are rare.
There have been very rare reports of abnormal tube-like connections between internal organs and skin or other tissues that are not normally connected.
There have been very rare reports of patients developing a hole in the septum of the nose, the structure that separates the nostrils. Symptoms may include nose bleeds, nasal congestion or infection, or whistling sounds when breathing.
Tell your doctor or dentist if you experience pain in the mouth, teeth and/or jaw, swelling or sores inside the mouth, loosening of a tooth, or numbness or a feeling of heaviness in the jaw. These could be signs and symptoms of bone damage in the jaw (osteonecrosis).
Some side effects are more common in elderly patients. These include blood clots in the arteries, which can lead to a stroke or a heart attack. In addition, elderly patients have a higher risk of a reduction in the number of white cells in the blood and cells that help the blood clot. Other side effects reported with a higher frequency in elderly patients were diarrhoea, sickness, headache and fatigue.
This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects not yet known.
Tell your doctor if you notice anything else that is making you feel unwell, even if it is not on this list.
Ask your doctor or pharmacist if you don't understand anything in this list.
After receiving AVASTIN
Storage
AVASTIN will be stored in the pharmacy or on the hospital ward in a refrigerator at a temperature between 2-8°C.
Disposal
AVASTIN is for single use only.
The vials should be used once only and any remaining contents should be discarded.
Product description
Availability
AVASTIN is available as 100 mg and 400 mg single-dose vials.
What AVASTIN looks like
AVASTIN is a clear to slightly opaque, colourless to pale brown solution.
Ingredients
Active ingredient
Bevacizumab
Inactive ingredients
trehalose dihydrate
sodium phosphate - monobasic monohydrate
sodium phosphate - dibasic
polysorbate 20
water for injections
Distributor
AVASTIN is distributed by:
Roche Products Pty Limited
ABN 70 000 132 865
4-10 Inman Road
Dee Why NSW 2099
AUSTRALIA
Customer enquiries: 1800 233 950
Please check with your pharmacist for the latest Consumer Medicine Information.
Australian Registration Numbers
100 mg/4 mL AUST R 99755
400 mg/16 mL AUST R 99757
This leaflet was prepared on 13 May 2011
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