You should not breast-feed while being treated with AVASTIN and for at least 6 months after the last dose. AVASTIN may interfere with the growth and development of your baby.
4. you have any other health problems, especially the following:

inflammation of the bowel (symptoms may include fever, vomiting, diarrhoea and stomach pain) or stomach ulcers,
hypertension (high blood pressure) - it is important to follow all your doctor's instructions to control your blood pressure
history of blood clots or stroke, or you are taking medicine to prevent blood clots (e.g. warfarin)
you or anyone in your family suffer from bleeding problems
heart disease
5. you have had major surgery within the last 28 days or have a wound that has not healed properly

AVASTIN can cause an increased risk of post-operative bleeding or problems with wound healing.
6. you have had a blocked lung artery (pulmonary embolism)

AVASTIN may increase the risk of recurrence
7. you have ever received anthracyclines (e.g. doxorubicin), a specific type of chemotherapy used to treat some cancers, or have had radiotherapy to your chest AVASTIN can increase the risk of developing a weak heart.

8. you are 65 years of age or older

AVASTIN can increase the risk of blood clots which can lead to strokes or heart attacks in patients older than 65 years of age compared with younger patients.
9. you are allergic to any other medicines, foods, dyes or preservatives

If you have not told your doctor about any of the above, tell them before you start taking AVASTIN.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you have bought from a pharmacy, supermarket or health food shop.
Tell your doctor if you have recently received, or are receiving, radiotherapy.
Some medicines may interfere with AVASTIN.
Some medicines may be affected by AVASTIN, or may affect how well it works. You may need to use different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.
Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking AVASTIN.
Ask your doctor or pharmacist if you are not sure about this list of medicines.
How AVASTIN is given
How it is given
AVASTIN solution is prepared by a health care professional.
AVASTIN is given by infusion into a vein (intravenous infusion) by a health care professional.
The first infusion is usually given over 90 minutes. If it is well tolerated the second infusion may be given over 60 minutes. Later infusions may be given over 30 minutes.
How much is given
Your dose depends on your body weight and the type of cancer to be treated. AVASTIN can be given either once every 2 weeks or once every 3 weeks. Your doctor will prescribe a dose of AVASTIN that is right for you.
If you have been given too much AVASTIN you may develop a severe migraine. If this happens tell your health care professional immediately.
How long is it given
The number of infusions you will receive depends on how you are responding to treatment. Your doctor will discuss this with you.
Continue using AVASTIN until your doctor tells you to stop.
If you miss a dose
Your doctor will decide when you should be given your next dose of AVASTIN.
While you are being treated with AVASTIN
Things you must do
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