During initial therapy with warfarin sodium tablets, the interference with heparin anticoagulation is of minimal clinical significance.

As heparin may affect the PT/INR, patients receiving both heparin and warfarin sodium tablets should have blood for PT/INR determination drawn at least:

5 hours after the last IV bolus dose of heparin, or
4 hours after cessation of a continuous IV infusion of heparin, or
24 hours after the last subcutaneous heparin injection.
HOW SUPPLIED
Warfarin Sodium Tablets, USP are available containing 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg or 10 mg of warfarin sodium, USP.

The 1 mg tablet is a dark pink round, scored tablet with "WF" above the score and "1" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-195-30
bottles of 30 tablets

The 2 mg tablet is a lavender round, scored tablet with "WF" above the score and "2" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-196-30
bottles of 30 tablets

NDC 51138-196-60
bottles of 60 tablets

The 2.5 mg tablet is a green round, scored tablet with "WF" above the score and"2.5" below the score on one side and"G" on the other side. They are available as follows:

NDC 51138-197-30
bottles of 100 tablets

The 3 mg tablet is a beige round, scored tablet with "WF" above the score and"3" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-198-30
bottles of 30 tablets

The 4 mg tablet is a blue round, scored tablet with "WF" above the score and "4" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-199-30
bottles of 30 tablets

The 5 mg tablet is a peach round, scored tablet with "WF" above the score and "5" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-200-30
bottles of 30 tablets

The 6 mg tablet is a greenish-blue round, scored tablet with "WF" above the score and "6" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-201-30
bottles of 30 tablets

The 7.5 mg tablet is a yellow round, scored tablet with "WF" above the score and "7.5" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-202-30
bottles of 30 tablets

The 10 mg tablet is a white to off-white round, scored tablet with "WF" above the score and "10" below the score on one side and "G" on the other side. They are available as follows:

NDC 51138-203-30
bottles of 100 tablets

Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]

Protect from light.

Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.

PHARMACIST: Dispense a Medication Guide with each prescription.

REFERENCES
Yasar U, Eliasson E, Dahl M, Johansson I, Ingelman-Sundberg M, Sjoqvist F. Validation of methods for CYP2C9 genotyping: Frequencies of mutant alleles in Swedish population. Biochem Biophys Res Comm. 1999; 254:628