n, men should discuss the possibility of sperm conservation with their doctor before starting treatment.
Use with caution in Decreased kidney function.
Decreased liver function or liver disease.
Not to be used inSevere or uncontrolled infection.
Breastfeeding.
People with high levels of bilirubin (a pigment produced by the liver).
People with severely decreased kidney function.
People with low numbers of white blood cells (neutropenia), platelets (thrombocytopenia) or haemoglobin in their blood.
People with raised liver enzymes or creatinine phosphokinase (CPK) levels.
This medicine is not recommended for children and adolescents.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine may cause serious birth defects in a developing baby. It should not be used during pregnancy unless considered essential by your doctor. Effective contraception should be used by women who themselves, or whose male partners, are receiving treatment with this medicine. Women should continue to use this contraception for at least three months after the medicine is stopped. Consult your doctor immediately if you think you could be pregnant.
Men being treated with this medicine should use condoms to avoid fathering a child, both during treatment and for five months after treatment is finished, if their partner could get pregnant and is not using contraception.
It is not known if this medicine passes into breast milk. Women should not breastfeed during treatment with this medicine and for three months after stopping the treatment.
Side effects Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
Disturbances of the gut, such as nausea and vomiting, constipation, diarrhoea, indigestion, abdominal pain.
Decrease in the numbers of white blood cells (neutropenia), platelets (thrombocytopenia) or red blood cells (anaemia) in the blood.
Fatigue, weakness or loss of strength (asthenia).
Loss of appetite and weight loss.
Headache.
Elevated levels of liver enzymes.
Injection site reaction.
Dizziness.
Problems with the nerves, for example causing changes in sensation such as pins and needles (paraesthesia) or numbness.
Shortness of breath (dyspnoea).
Pain in muscle or joints (myalgia or arthralgia).
Hair loss (alopecia).
Fever.
Low blood pressure (hypotension).
Swollen ankles (peripheral oedema).
Difficulty sleeping (insomnia).
Inflammation of the lining of the mouth (stomatitis).
Bacterial, viral or fungal infections, sometimes serious.
Muscle breakdown (rhabdomyolysis).
The side effects listed above
