0 (0%)
Very common
Glossodynia
63 (11.6%)
0 (0%)
0 (0%)
Very common
Oral pain
62 (11.4%)
2 (0.4%)
0 (0%)
Very common
Flatulence
60 (11.0%)
0 (0%)
0 (0%)
Very common
Dry mouth
56 (10.3%)
0 (0%)
0 (0%)
Common
Gastroesophageal reflux disease
50 (9.2%)
2 (0.4%)
0 (0%)
Common
Dysphagia
20 (3.7%)
2 (0.4%)
1 (0.2%)
Common
Cheilitis
19 (3.5%)
1 (0.2%)
0 (0%)
Common
Gingival bleeding
18 (3.3%)
0 (0%)
0 (0%)
Common
Haemorrhoids
18 (3.3%)
0 (0%)
0 (0%)
Common
Proctalgia
17 (3.1%)
1 (0.2%)
0 (0%)
Common
Mouth ulceration
16 (2.9%)
0 (0%)
1 (0.2%)
Common
Stomach discomfort
12 (2.2 %)
0 (0%)
0 (0%)
Common
Eructation
11 (2.0%)
0 (0%)
0 (0%)
Common
Rectal haemorrhage
13 (2.4%)
0 (0%)
0 (0%)
Skin and subcutaneous tissue disorders
Very common
Palmar-plantar erythrodysaesthesia syndrome
139 (25.5%)
44 (8.1%)
0 (0%)
Very common
Yellow discolouration/ Skin discolouration/ Pigment disorder
153 (28.1%)
1 (0.2%)
0 (0%)
Very common
Rash
122 (22.4%)
3 (0.6%)
1 (0.2%)
Very common
Dry skin
108 (19.9%)
1 (0.2%)
0 (0%)
Very common
Hair colour changes
103 (18.9%)
0 (0%)
0 (0%)
Very common
Alopecia
64 (11.8%)
0 (0%)
0 (0%)
Very Common
Erythema
58 (10.7%)
2 (0.4%)
0 (0%)
Common
Skin exfoliation
47 (8.6%)
4 (0.7%)
0 (0%)
Common
Skin reaction/skin disorder
42 (7.7%)
6 (1.1%)
0 (0%)
Common
Pruritus
40 (7.4%)
1 (0.2%)
0 (0%)
Common
Periorbital oedema
31 (5.7%)
1 (0.2%)
0 (0%)
Common
Dermatitis
26 (4.8%)
4 (0.7%)
0 (0%)
Common
Skin lesion
27 (5.0%)
1 (0.2%)
0 (0%)
Common
Nail disorder/discolouration
25 (4.6%)
0 (0%)
0 (0%)
Common
Blister
23 (4.2%)
1 (0.2%)
0 (0%)
Common
Hyperkeratosis
22 (4.0%)
4 (0.7%)
0 (0%)
Common
Acne
19 (3.5%)
0 (0%)
0 (0%)
Musculoskeletal and connective tissue disorders
Very common
Pain in extremity
96 (17.6%)
6 (1.1%)
0 (0%)
Common
Arthralgia
51 (9.4%)
1 (0.2%)
0 (0%)
Common
Myalgia
49 (9.0%)
2 (0.4%)
0 (0%)
Common
Muscle Spasm
26 (4.8%)
0 (0%)
0 (0%)
Common
Back pain
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